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Topoisomerase 1 Dmel_CG6146
Protein found in Drosophila melanogaster
Top 1
CG6146-PE
Top1-PB
topoisomerase1
CG6146-PB
CG6146-PC
CG6146-PD
Top1-PD
CG6146-PA
Top1
Top1-PE
CG6146 gene product from transcript CG6146-RA
Top1-PC
Top1-PA
topoisomerase I
topoisomerase 1
type I topoisomerase
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P30189
part of
DNA topoisomerase I, DNA binding, N-terminal domain 2
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P30189
DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P30189
DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P30189
DNA topoisomerase I, subgroup
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P30189
DNA topoisomerase I, catalytic core, alpha/beta subdomain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P30189
DNA breaking-rejoining enzyme, catalytic core
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P30189
DNA topoisomerase I, DNA binding, N-terminal domain 1
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P30189
DNA topoisomerase I domain, eukaryotic-type, protein family
1 reference
based on heuristic
inferred from protein domain or family
DNA topoisomerase I, DNA binding, eukaryotic-type, protein family
1 reference
based on heuristic
inferred from protein domain or family
Topoisomerase I C-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
DNA topoisomerase I, catalytic core, eukaryotic-type, protein family
1 reference
based on heuristic
inferred from protein domain or family
DNA topoisomerase I, active site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Drosophila melanogaster
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P30189
encoded by
Top1
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P30189
molecular function
DNA binding
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P30189
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IEA
DNA topoisomerase activity
determination method
IDA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P30189
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IEA
retrieved
8 April 2019
stated in
Targeting to transcriptionally active loci by the hydrophilic N-terminal domain of Drosophila DNA topoisomerase I.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IDA
DNA topoisomerase type I (single strand cut, ATP-independent) activity
determination method
IBA
IDA
IEA
4 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IEA
retrieved
8 April 2019
stated in
Isolation and characterization of a gene encoding DNA topoisomerase I in Drosophila melanogaster
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IDA
retrieved
8 April 2019
stated in
Drosophihlatopoisomerase I: isolation, purificatioann and characterization
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IBA
isomerase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P30189
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IEA
cell component
nucleus
determination method
IDA
IEA
4 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P30189
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IEA
retrieved
8 April 2019
stated in
Essential functions of DNA topoisomerase I in Drosophila melanogaster.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IDA
retrieved
8 April 2019
stated in
Drosophihlatopoisomerase I: isolation, purificatioann and characterization
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IDA
retrieved
8 April 2019
stated in
Targeting to transcriptionally active loci by the hydrophilic N-terminal domain of Drosophila DNA topoisomerase I.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IDA
chromosome
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IEA
polytene chromosome
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
The SR protein B52/SRp55 is required for DNA topoisomerase I recruitment to chromatin, mRNA release and transcription shutdown.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IDA
polytene chromosome puff
determination method
IDA
2 references
retrieved
8 April 2019
stated in
Drosophila DNA topoisomerase I is associated with transcriptionally active regions of the genome
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IDA
retrieved
8 April 2019
stated in
Targeting to transcriptionally active loci by the hydrophilic N-terminal domain of Drosophila DNA topoisomerase I.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IDA
nucleolus
determination method
IBA
IDA
2 references
retrieved
8 April 2019
stated in
Drosophila DNA topoisomerase I is associated with transcriptionally active regions of the genome
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IBA
cytoplasm
determination method
IDA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P30189
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IEA
retrieved
8 April 2019
stated in
Essential functions of DNA topoisomerase I in Drosophila melanogaster.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IDA
cytosol
determination method
HDA
1 reference
retrieved
8 April 2019
stated in
Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
HDA
replication fork protection complex
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IBA
biological process
instar larval development
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Essential functions of DNA topoisomerase I in Drosophila melanogaster.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IMP
DNA replication
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IBA
DNA topological change
determination method
IBA
IDA
IEA
3 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IEA
retrieved
8 April 2019
stated in
Drosophihlatopoisomerase I: isolation, purificatioann and characterization
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IBA
chromatin remodeling
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IBA
chromosome segregation
determination method
IBA
IMP
2 references
retrieved
8 April 2019
stated in
Essential functions of DNA topoisomerase I in Drosophila melanogaster.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IMP
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IBA
multicellular organism development
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
DNA topoisomerase I is essential in Drosophila melanogaster
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IMP
cell population proliferation
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Essential functions of DNA topoisomerase I in Drosophila melanogaster.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IMP
chromosome condensation
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Essential functions of DNA topoisomerase I in Drosophila melanogaster.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IMP
regulation of embryonic development
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Essential functions of DNA topoisomerase I in Drosophila melanogaster.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IMP
oogenesis
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Essential functions of DNA topoisomerase I in Drosophila melanogaster.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30189
determination method
IMP
has part(s)
DNA topoisomerase I, DNA binding, eukaryotic-type
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P30189
DNA topoisomerase I, active site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P30189
DNA topoisomerase I, catalytic core, eukaryotic-type
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P30189
DNA topoisomerase I domain, eukaryotic-type
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P30189
Topoisomerase I C-terminal domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P30189
Identifiers
RefSeq protein ID
NP_001014742
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
32458
NP_001245679
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
32458
NP_001285267
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
32458
NP_511161
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
32458
NP_727841
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
32458
UniProt protein ID
P30189
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P30189
Ensembl protein ID
FBpp0073823
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0073823
FBpp0099689
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0099689
FBpp0073822
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0073822
FBpp0300905
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0300905
FBpp0309379
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0309379
Sitelinks
Wikipedia
(0 entries)
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Wikibooks
(0 entries)
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Wikinews
(0 entries)
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Wikiquote
(0 entries)
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Wikisource
(0 entries)
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Wikiversity
(0 entries)
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Wikivoyage
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Wiktionary
(0 entries)
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Multilingual sites
(0 entries)
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