(Q29815568)

English

Fused Dmel_CG6551

Protein found in Drosophila melanogaster

CG6551-PA
CG6551 gene product from transcript CG6551-RA
fu
fu-PA
fused

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23647

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

protein kinase activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

protein serine/threonine kinase activity

determination method

5 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

10 September 2018

Protein kinases and phosphatases in the Drosophila genome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

10 September 2018

A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

10 September 2018

Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

protein binding

determination method

8 references

9 May 2019

The Fused/Smurf complex controls the fate of Drosophila germline stem cells by generating a gradient BMP response

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

The sex determination master switch, Sex-lethal, responds to Hedgehog signaling in the Drosophila germline.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

kinase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

transferase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

protein serine/threonine kinase activity

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

8 April 2019

Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

8 April 2019

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

protein homodimerization activity

determination method

1 reference

9 May 2019

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

protein serine/threonine kinase activity

determination method

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

determination method

1 reference

9 May 2019

The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

Hedgehog signaling complex

determination method

1 reference

9 May 2019

Identification of a tetrameric hedgehog signaling complex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

protein-containing complex

determination method

1 reference

9 May 2019

Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

biological process

smoothened signaling pathway

determination method

4 references

10 September 2018

Regulation of Hedgehog signaling: a complex story

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

10 September 2018

The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

10 September 2018

The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

10 September 2018

Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

positive regulation of hh target transcription factor activity

determination method

multicellular organism development

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

phosphorylation

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

regulation of proteolysis

determination method

1 reference

10 September 2018

Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

negative regulation of BMP signaling pathway

determination method

1 reference

9 May 2019

The Fused/Smurf complex controls the fate of Drosophila germline stem cells by generating a gradient BMP response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

positive regulation of protein ubiquitination

determination method

1 reference

9 May 2019

The Fused/Smurf complex controls the fate of Drosophila germline stem cells by generating a gradient BMP response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

regulation of protein stability

determination method

1 reference

9 May 2019

Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

intraciliary transport

determination method

1 reference

9 May 2019

Cilia-mediated hedgehog signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

protein phosphorylation

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

smoothened signaling pathway

determination method

10 references

7 November 2018

Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

7 November 2018

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

7 November 2018

Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

7 November 2018

Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

7 November 2018

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

7 November 2018

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

7 November 2018

Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

7 November 2018

The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

7 November 2018

The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

7 November 2018

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P23647&geneProductId=UniProtKB:P23647

determination method

germarium-derived egg chamber formation

determination method

1 reference

9 May 2019

Fused-dependent Hedgehog signal transduction is required for somatic cell differentiation during Drosophila egg chamber formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

protein autophosphorylation

determination method

1 reference

9 May 2019

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

smoothened signaling pathway

determination method

11 references

9 May 2019

Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

9 May 2019

The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

wing disc pattern formation

determination method

1 reference

9 May 2019

The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

positive regulation of hh target transcription factor activity

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23647

determination method

serine/threonine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23647

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23647

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P23647

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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