(Q29815734)

English

Anterior pharynx defective 1 Dmel_CG2855

Protein found in Drosophila melanogaster

CG2855 gene product from transcript CG2855-RB
CG2855-PB
presenilin stabilization factor
aph-1-PA
presenilin enhancer-1
aph-1-PB
anterior pharynx defective 1
aph-1
CG2855-PA

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Statements

1 reference

25 May 2022

Gamma-secretase subunit Aph-1

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9VQG2

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

endopeptidase activity

determination method

IMP

endopeptidase activity

3 references

8 April 2019

The role of presenilin cofactors in the gamma-secretase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

8 April 2019

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

1 reference

8 April 2019

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

determination method

IDA

endoplasmic reticulum

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

determination method

IBA

integral component of plasma membrane

3 references

8 April 2019

The role of presenilin cofactors in the gamma-secretase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

8 April 2019

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

1 reference

8 April 2019

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

determination method

IDA

gamma-secretase complex

1 reference

16 July 2018

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VQG2&geneProductId=UniProtKB:Q9VQG2

determination method

IPI

biological process

Notch receptor processing

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

determination method

IBA

regulation of Notch signaling pathway

1 reference

10 September 2018

Activation of Notch in lgd mutant cells requires the fusion of late endosomes with the lysosome.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VQG2&geneProductId=UniProtKB:Q9VQG2

determination method

IGI

positive regulation of catalytic activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

determination method

IEA

Notch signaling pathway

3 references

10 September 2018

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VQG2&geneProductId=UniProtKB:Q9VQG2

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VQG2&geneProductId=UniProtKB:Q9VQG2

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VQG2&geneProductId=UniProtKB:Q9VQG2

determination method

IBA

membrane protein ectodomain proteolysis

1 reference

8 April 2019

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

determination method

IDA

Notch signaling pathway

5 references

8 April 2019

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

8 April 2019

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

8 April 2019

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

determination method

IBA

Notch receptor processing, ligand-dependent

1 reference

8 April 2019

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VQG2

determination method

IGI

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

(Q29815734)

Anterior pharynx defective 1 Dmel_CG2855

Statements

Identifiers

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