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(Q29815761)
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Presenilin enhancer Dmel_CG33198
Protein found in Drosophila melanogaster
CG33198-PA
presenilin enhancer 2
CG33198-PB
pen-2-PA
pen-2-PB
presenilin enhancer
CG33198 gene product from transcript CG33198-RB
pen-2
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q86BE9
part of
Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q86BE9
found in taxon
Drosophila melanogaster
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q86BE9
encoded by
pen-2
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q86BE9
cell component
late endosome
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86BE9
determination method
IDA
membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q86BE9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86BE9
determination method
IEA
integral component of membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q86BE9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86BE9
determination method
IEA
recycling endosome
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86BE9
determination method
IDA
gamma-secretase complex
determination method
IPI
1 reference
retrieved
16 July 2018
stated in
In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86BE9&geneProductId=UniProtKB:Q86BE9
determination method
IPI
gamma-secretase complex
determination method
IBA
IPI
2 references
retrieved
8 April 2019
stated in
In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86BE9
determination method
IPI
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86BE9
determination method
IBA
biological process
Notch signaling pathway
determination method
IEA
1 reference
retrieved
10 September 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q86BE9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86BE9&geneProductId=UniProtKB:Q86BE9
determination method
IEA
Notch receptor processing
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86BE9
determination method
IBA
membrane protein ectodomain proteolysis
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86BE9
determination method
IDA
Notch signaling pathway
determination method
IEA
IGI
IMP
3 references
retrieved
8 April 2019
stated in
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86BE9
determination method
IMP
retrieved
8 April 2019
stated in
In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86BE9
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q86BE9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86BE9
determination method
IEA
amyloid-beta formation
determination method
IDA
IMP
2 references
retrieved
8 April 2019
stated in
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86BE9
determination method
IMP
retrieved
8 April 2019
stated in
In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86BE9
determination method
IDA
Notch receptor processing, ligand-dependent
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86BE9
determination method
IGI
Identifiers
RefSeq protein ID
NP_001286566
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
251430
NP_788401
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
251430
UniProt protein ID
Q86BE9
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q86BE9
Ensembl protein ID
FBpp0309291
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0309291
FBpp0088783
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0088783
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