(Q29815953)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VA38

AGC-kinase, C-terminal domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 reference

1 January 2018

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 reference

1 January 2018

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

6 references

1 January 2018

1 January 2018

Protein kinases and phosphatases in the Drosophila genome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

NAS

1 January 2018

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 January 2018

protein binding

6 references

1 January 2018

Ajuba LIM proteins are negative regulators of the Hippo signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 January 2018

Control of cell proliferation and apoptosis by mob as tumor suppressor, mats

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 January 2018

Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 January 2018

Riquiqui and minibrain are regulators of the hippo pathway downstream of Dachsous

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 January 2018

Zyxin links fat signaling to the hippo pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 January 2018

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 reference

1 January 2018

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 reference

1 January 2018

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 reference

1 January 2018

microtubule organizing center

cell component

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 reference

1 January 2018

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 reference

1 January 2018

adherens junction

1 reference

1 January 2018

Cytoskeletal tension inhibits Hippo signaling through an Ajuba-Warts complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

biological process

G1 phase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 reference

1 January 2018

cell fate specification

1 reference

1 January 2018

Opposite feedbacks in the Hippo pathway for growth control and neural fate.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

border follicle cell migration

1 reference

1 January 2018

The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

open tracheal system development

1 reference

1 January 2018

A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

imaginal disc growth

1 reference

1 January 2018

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

negative regulation of cell population proliferation

Mechanisms of size control.

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 January 2018

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 January 2018

The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

regulation of cell shape

1 reference

1 January 2018

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

response to ionizing radiation

1 reference

1 January 2018

Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

regulation of glucose metabolic process

1 reference

1 January 2018

Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 reference

1 January 2018

peptidyl-serine phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 reference

1 January 2018

hippo signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

1 reference

1 January 2018

regulation of cell population proliferation

1 reference

1 January 2018

Regulation of Cell Cycles in Drosophila Development: Intrinsic and Extrinsic Cues

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

1 reference

1 January 2018

Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

positive regulation of apoptotic process

1 reference

1 January 2018

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

apical protein localization

1 reference

1 January 2018

The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

R8 cell fate specification

1 reference

1 January 2018

The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

regulation of imaginal disc growth

1 reference

1 January 2018

Regulation of Cell Cycles in Drosophila Development: Intrinsic and Extrinsic Cues

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

negative regulation of transcription, DNA-templated

1 reference

1 January 2018

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

regulation of dendrite morphogenesis

1 reference

1 January 2018

The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

negative regulation of glial cell proliferation

1 reference

1 January 2018

Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

stem cell proliferation

1 reference

1 January 2018

Hippo signaling regulatesDrosophilaintestine stem cell proliferation through multiple pathways

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38

negative regulation of canonical Wnt signaling pathway

1 reference

1 January 2018

The Hippo pathway regulates Wnt/beta-catenin signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VA38&geneProductId=UniProtKB:Q9VA38