(Q29817164)

Axin-1

1 reference

RGS domain superfamily

1 reference

RGS, subdomain 1/3

1 reference

DIX domain superfamily

1 reference

DIX domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Axin beta-catenin binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Regulator of G protein signalling

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

GTPase activator activity

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9V407&geneProductId=UniProtKB:Q9V407

signaling receptor binding

IBA

1 reference

8 April 2019

Wnt pathway activation by ADP-ribosylation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

1 reference

8 April 2019

In vivo analysis in Drosophila reveals differential requirements of contact residues in Axin for interactions with GSK3beta or beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

In vivo analysis in Drosophila reveals differential requirements of contact residues in Axin for interactions with GSK3beta or beta-catenin

IPI

protein kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

signaling receptor complex adaptor activity

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

1 reference

8 April 2019

Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

8 April 2019

Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

8 April 2019

Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

1 reference

8 April 2019

Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

segment polarity determination

3 references

8 April 2019

Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

8 April 2019

The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

8 April 2019

A Drosophila Axin homolog, Daxin, inhibits Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

dorsal/ventral pattern formation, imaginal disc

1 reference

8 April 2019

The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

eye-antennal disc morphogenesis

1 reference

8 April 2019

The role of Wingless signaling in establishing the anteroposterior and dorsoventral axes of the eye disc.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

1 reference

8 April 2019

Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

imaginal disc-derived wing margin morphogenesis

TAS

1 reference

8 April 2019

A Drosophila Axin homolog, Daxin, inhibits Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

Hyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities

regulation of cell death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

IGI

Wnt signaling pathway

1 reference

8 April 2019

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

somatic stem cell population maintenance

1 reference

8 April 2019

Wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

chitin-based larval cuticle pattern formation

3 references

8 April 2019

Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

8 April 2019

The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

8 April 2019

A Drosophila Axin homolog, Daxin, inhibits Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

Hyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities

response to starvation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

positive regulation of GTPase activity

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9V407&geneProductId=UniProtKB:Q9V407

1 reference

8 April 2019

Wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

negative regulation of canonical Wnt signaling pathway

11 references

8 April 2019

Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

8 April 2019

Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

8 April 2019

The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

8 April 2019

Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

8 April 2019

Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

8 April 2019

A Drosophila Axin homolog, Daxin, inhibits Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

8 April 2019

Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

8 April 2019

The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

8 April 2019

A Drosophila Axin homolog, Daxin, inhibits Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

8 April 2019

The role of Wingless signaling in establishing the anteroposterior and dorsoventral axes of the eye disc.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

8 April 2019

RanBP3 enhances nuclear export of active (beta)-catenin independently of CRM1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

ovarian follicle cell development

IDA

1 reference

8 April 2019

Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

positive regulation of signal transduction

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9V407

Axin beta-catenin binding

has part(s)

1 reference

DIX domain

1 reference

RGS domain

1 reference