(Q29817352)

Leucine-rich repeat domain superfamily

1 reference

Leucine-rich repeat N-terminal domain, protein family

1 reference

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

Cysteine-rich flanking region, C-terminal domain, protein family

1 reference

Leucine-rich repeat, typical subtype, protein family

1 reference

BspA type Leucine rich repeat region, protein family

1 reference

Leucine-rich repeat, protein family

1 reference

transmembrane signaling receptor activity

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

1 January 2018

The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

6 references

8 April 2019

Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Drosophila MyD88 is an adapter in the Toll signaling pathway

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Tehao functions in the Toll pathway in Drosophila melanogaster: possible roles in development and innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Spätzle.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 reference

8 April 2019

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

cytokine receptor activity

IPI

1 reference

8 April 2019

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

3 references

8 April 2019

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Role of the Spatzle Pro-domain in the generation of an active toll receptor ligand.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Structure of the Toll-Spatzle complex, a molecular hub in Drosophila development and innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

1 reference

8 April 2019

Endocytosis is required for Toll signaling and shaping of the Dorsal/NF-kappaB morphogen gradient during Drosophila embryogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal-ventral pattern formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

Mapping organelle proteins and protein complexes in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

Plasma membrane polarity and compartmentalization are established before cellularization in the fly embryo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

Endocytic pathway is required for Drosophila Toll innate immune signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

external side of plasma membrane

1 reference

8 April 2019

Virus recognition by Toll-7 activates antiviral autophagy in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

1 reference

1 January 2018

Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal-ventral pattern formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

integral component of membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

1 reference

8 April 2019

Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal-ventral pattern formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal-ventral pattern formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Mapping organelle proteins and protein complexes in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

integral component of plasma membrane

HDA

5 references

8 April 2019

Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal-ventral pattern formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Endocytic pathway is required for Drosophila Toll innate immune signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Plasma membrane polarity and compartmentalization are established before cellularization in the fly embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

protein-containing complex

1 reference

8 April 2019

Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Spätzle.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

defense response to oomycetes

IPI

biological process

1 reference

8 April 2019

Toll-deficient Drosophila is susceptible to Pythium insidiosum infection.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

immune system process

1 reference

8 April 2019

1 reference

1 January 2018

The antimicrobial host defense of Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

positive regulation of antibacterial peptide biosynthetic process

1 reference

1 January 2018

Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

positive regulation of antifungal peptide biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

zygotic specification of dorsal/ventral axis

1 reference

1 January 2018

The immune response of Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 reference

8 April 2019

The ultrastructural interactions of identified pre- and postsynaptic cells during synaptic target recognition in Drosophila embryos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

1 reference

8 April 2019

Expression, regulation, and requirement of the toll transmembrane protein during dorsal vessel formation in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

larval somatic muscle development

1 reference

8 April 2019

The Toll pathway is required in the epidermis for muscle development in the Drosophila embryo.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

Flies kNOw how to signal.

response to bacterium

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

embryonic pattern specification

NAS

1 reference

1 January 2018

The evolution and genetics of innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

dorsal/ventral axis specification

5 references

1 January 2018

Toll we meet again....

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

The antimicrobial host defense of Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

Conservation and divergence in molecular mechanisms of axis formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

synaptic target inhibition

1 reference

8 April 2019

Drosophila Tey represses transcription of the repulsive cue Toll and generates neuromuscular target specificity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

antimicrobial humoral response

1 reference

1 January 2018

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

antifungal humoral response

IGI

1 reference

1 January 2018

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 reference

1 January 2018

The antimicrobial host defense of Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

regulation of melanization defense response

1 reference

1 January 2018

Caenorhabditis elegans: an emerging genetic model for the study of innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

Role of Toll-like receptors in pathogen recognition.

innate immune response

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

The complexity of genetic variation in a simple immune system

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

regulation of hemocyte differentiation

1 reference

1 January 2018

A directed screen for genes involved in Drosophila blood cell activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

defense response to Gram-positive bacterium

3 references

1 January 2018

The immune response of Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

Role of Toll-like receptors in pathogen recognition.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

defense response to fungus

4 references

1 January 2018

The immune response of Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

Drosophila: the genetics of innate immune recognition and response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

Role of Toll-like receptors in pathogen recognition.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

regulation of embryonic pattern specification

1 reference

8 April 2019

Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

toll-like receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

positive regulation of antimicrobial peptide production

IBA

3 references

8 April 2019

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

IBA

Toll signaling pathway

12 references

8 April 2019

8 April 2019

Differential display of peptides induced during the immune response of Drosophila: a matrix-assisted laser desorption ionization time-of-flight mass spectrometry study

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Cactus protein degradation mediates Drosophila dorsal-ventral signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Functional interactions between the pelle kinase, Toll receptor, and tube suggest a mechanism for activation of dorsal.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Multimerization and interaction of Toll and Spätzle in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Cytokine Spatzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

dorsal/ventral axis specification

4 references

1 January 2018

Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 January 2018

Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

cytokine-mediated signaling pathway

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

The lesswright mutation activates Rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster.

hemocyte proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

innate immune response

3 references

8 April 2019

8 April 2019

Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

defense response to Gram-positive bacterium

IBA

1 reference

8 April 2019

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

antifungal innate immune response

1 reference

1 January 2018

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08953&geneProductId=UniProtKB:P08953

1 reference

8 April 2019

Toll pathway is required for wound-induced expression of barrier repair genes in the Drosophila epidermis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

dorsal/ventral axis specification

5 references

8 April 2019

Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

8 April 2019

Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

positive regulation of hemocyte proliferation

IGI

1 reference

8 April 2019

The lesswright mutation activates Rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

negative regulation of multicellular organism growth

1 reference

8 April 2019

Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P3 Production and Akt Activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08953

negative regulation of insulin receptor signaling pathway

BspA type Leucine rich repeat region

1 reference

cysteine-rich flanking region, C-terminal

1 reference

leucine-rich repeat N-terminal domain

1 reference

Toll/interleukin-1 receptor homology (TIR) domain

1 reference

leucine-rich repeat, typical subtype

1 reference

Leucine-rich repeat

1 reference