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(Q29817355)
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Pancreatic eIF-2alpha kinase Dmel_CG2087
Protein found in Drosophila melanogaster
CG2087-PB
PEK-PA
PEK-PC
PERK
PEK-PB
CG2087 gene product from transcript CG2087-RA
CG2087-PA
pancreatic eIF-2alpha kinase
pancreatic eIF2alpha kinase
protein kinase RNA-like endoplasmic reticulum kinase
CG2087-PC
PEK
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9NIV1
part of
Quinoprotein alcohol dehydrogenase-like superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NIV1
Protein kinase-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NIV1
WD40/YVTN repeat-like-containing domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NIV1
Protein kinase domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Pyrrolo-quinoline quinone beta-propeller repeat, protein family
1 reference
based on heuristic
inferred from protein domain or family
Protein kinase, ATP binding site, protein family
1 reference
based on heuristic
inferred from protein domain or family
Serine/threonine-protein kinase, active site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Drosophila melanogaster
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9NIV1
encoded by
PEK
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9NIV1
molecular function
nucleotide binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NIV1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IEA
protein kinase activity
determination method
IEA
NAS
2 references
retrieved
16 July 2018
stated in
Protein kinases and phosphatases in the Drosophila genome
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NIV1&geneProductId=UniProtKB:Q9NIV1
determination method
NAS
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NIV1&geneProductId=UniProtKB:Q9NIV1
determination method
IEA
protein serine/threonine kinase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NIV1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IEA
elongation factor-2 kinase activity
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Functional characterization of Drosophila melanogaster PERK eukaryotic initiation factor 2alpha (eIF2alpha) kinase.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IDA
ATP binding
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NIV1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IEA
kinase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NIV1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IEA
transferase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NIV1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IEA
protein kinase activity
determination method
IBA
IEA
NAS
3 references
retrieved
8 April 2019
stated in
Protein kinases and phosphatases in the Drosophila genome
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IBA
eukaryotic translation initiation factor 2alpha kinase activity
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IBA
cell component
endoplasmic reticulum
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NIV1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IEA
endoplasmic reticulum membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NIV1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IEA
membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NIV1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IEA
integral component of membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NIV1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IEA
cytosolic ribosome
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IBA
biological process
regulation of translation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NIV1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IEA
protein phosphorylation
determination method
IEA
NAS
2 references
retrieved
8 April 2019
stated in
Protein kinases and phosphatases in the Drosophila genome
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IEA
response to unfolded protein
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NIV1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IEA
regulation of G2/M transition of mitotic cell cycle
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IMP
positive regulation of autophagy
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Myc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogaster
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IMP
phosphorylation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NIV1
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IEA
PERK-mediated unfolded protein response
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
The defender against apoptotic cell death 1 gene is required for tissue growth and efficient N-glycosylation in Drosophila melanogaster
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IGI
positive regulation of JNK cascade
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
The defender against apoptotic cell death 1 gene is required for tissue growth and efficient N-glycosylation in Drosophila melanogaster
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IMP
regulation of translational initiation by eIF2 alpha phosphorylation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NIV1
determination method
IEA
has part(s)
Pyrrolo-quinoline quinone beta-propeller repeat
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NIV1
protein kinase domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NIV1
protein kinase, ATP binding site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NIV1
serine/threonine-protein kinase, active site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NIV1
Identifiers
RefSeq protein ID
NP_001262282
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
40653
NP_001262283
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
40653
NP_649538
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
40653
UniProt protein ID
Q9NIV1
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9NIV1
Ensembl protein ID
FBpp0078417
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0078417
FBpp0303059
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0303059
FBpp0303060
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0303060
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