(Q29817442)

English

Tolloid Dmel_CG6868

Protein found in Drosophila melanogaster

tld
tld-PA
tolloid
CG6868-PA
CG6868 gene product from transcript CG6868-RA

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Spermadhesin, CUB domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25723

Bone morphogenetic protein 1/tolloid-like protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25723

Metallopeptidase, catalytic domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25723

CUB domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase, metallopeptidase family

1 reference

based on heuristic

inferred from protein domain or family

Tolloid/BMP1 peptidase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase M12A family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like calcium-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like calcium-binding, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

metalloendopeptidase activity

determination method

3 references

1 January 2018

Conservation and divergence in molecular mechanisms of axis formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

1 January 2018

Twisted perspective: new insights into extracellular modulation of BMP signaling during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

calcium ion binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

peptidase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

zinc ion binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

hydrolase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

protein binding

determination method

1 reference

5 June 2018

Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25723&geneProductId=UniProtKB:P25723

determination method

metalloendopeptidase activity

determination method

4 references

8 April 2019

Twisted perspective: new insights into extracellular modulation of BMP signaling during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

8 April 2019

Conservation and divergence in molecular mechanisms of axis formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

8 April 2019

The metalloprotease tolloid-related and its TGF-beta-like substrate Dawdle regulate Drosophila motoneuron axon guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

metalloendopeptidase activity

determination method

6 references

9 May 2019

Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

9 May 2019

The metalloprotease tolloid-related and its TGF-beta-like substrate Dawdle regulate Drosophila motoneuron axon guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

9 May 2019

Interpretation of a BMP activity gradient in Drosophila embryos depends on synergistic signaling by two type I receptors, SAX and TKV.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

9 May 2019

Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

9 May 2019

Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

biological process

determination method

multicellular organism development

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

maternal specification of dorsal/ventral axis, oocyte, soma encoded

determination method

1 reference

9 May 2019

Graded maternal short gastrulation protein contributes to embryonic dorsal-ventral patterning by delayed induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

terminal region determination

determination method

1 reference

5 June 2018

Zygotic genes that mediate torso receptor tyrosine kinase functions in the Drosophila melanogaster embryo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25723&geneProductId=UniProtKB:P25723

determination method

amnioserosa formation

determination method

1 reference

9 May 2019

Investigation of leading edge formation at the interface of amnioserosa and dorsal ectoderm in the Drosophila embryo.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

torso signaling pathway

determination method

1 reference

5 June 2018

Zygotic genes that mediate torso receptor tyrosine kinase functions in the Drosophila melanogaster embryo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25723&geneProductId=UniProtKB:P25723

determination method

imaginal disc-derived wing vein morphogenesis

determination method

1 reference

9 May 2019

Matching catalytic activity to developmental function: tolloid-related processes Sog in order to help specify the posterior crossvein in the Drosophila wing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

embryonic pattern specification

determination method

1 reference

9 May 2019

Cell fate determination in embryonic ectoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

negative regulation of gene expression

determination method

1 reference

1 January 2018

Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

protein processing

determination method

1 reference

9 May 2019

The metalloprotease tolloid-related and its TGF-beta-like substrate Dawdle regulate Drosophila motoneuron axon guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

regulation of transforming growth factor beta receptor signaling pathway

determination method

1 reference

8 April 2019

Conservation and divergence in molecular mechanisms of axis formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

positive regulation of BMP signaling pathway

determination method

1 reference

1 January 2018

Twisted perspective: new insights into extracellular modulation of BMP signaling during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

positive regulation of BMP signaling pathway

determination method

4 references

8 April 2019

Twisted perspective: new insights into extracellular modulation of BMP signaling during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

8 April 2019

Two domains of the tolloid protein contribute to its unusual genetic interaction with decapentaplegic.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

8 April 2019

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

8 April 2019

Mutational analysis of the Drosophila tolloid gene, a human BMP-1 homolog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

positive regulation of activin receptor signaling pathway

determination method

1 reference

9 May 2019

The metalloprotease tolloid-related and its TGF-beta-like substrate Dawdle regulate Drosophila motoneuron axon guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

determination method

5 references

9 May 2019

Cell fate determination in embryonic ectoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

9 May 2019

Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

9 May 2019

Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

positive regulation of BMP signaling pathway

determination method

4 references

9 May 2019

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

9 May 2019

Two domains of the tolloid protein contribute to its unusual genetic interaction with decapentaplegic.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

9 May 2019

Mutational analysis of the Drosophila tolloid gene, a human BMP-1 homolog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

9 May 2019

Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25723

determination method

Peptidase, metallopeptidase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25723

EGF-like calcium-binding, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25723

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25723

EGF-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25723

EGF-like, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25723

Peptidase M12A domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25723

EGF-like calcium-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25723

EGF-type aspartate/asparagine hydroxylation site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25723

Tolloid/BMP1 peptidase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25723

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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