(Q29818405)

Armadillo-type fold

1 reference

Sterile alpha motif/pointed domain superfamily

1 reference

Protein Smaug, SAM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Smaug, PHAT analogous topology, protein family

1 reference

based on heuristic

inferred from protein domain or family

Sterile alpha motif domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

translation repressor activity, mRNA regulatory element binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

mRNA binding

1 reference

31 January 2018

SAM breaks its stereotype

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q23972&geneProductId=UniProtKB:Q23972

mRNA 3'-UTR binding

3 references

8 April 2019

SAM domains: uniform structure, diversity of function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

8 April 2019

Translational regulation and RNA localization in Drosophila oocytes and embryos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

protein binding

1 reference

8 April 2019

Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

myosin binding

1 reference

8 April 2019

Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

translation repressor activity

Translational regulation and RNA localization in Drosophila oocytes and embryos.

3 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q23972&geneProductId=UniProtKB:Q23972

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q23972&geneProductId=UniProtKB:Q23972

31 January 2018

31 January 2018

Smaug, a novel RNA-binding protein that operates a translational switch in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q23972&geneProductId=UniProtKB:Q23972

translation repressor activity

Translational regulation and RNA localization in Drosophila oocytes and embryos.

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

8 April 2019

8 April 2019

Smaug, a novel RNA-binding protein that operates a translational switch in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

cell component

P-body

1 reference

31 January 2018

P-body formation is a consequence, not the cause, of RNA-mediated gene silencing

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q23972&geneProductId=UniProtKB:Q23972

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

3 references

8 April 2019

8 April 2019

Smaug, a novel RNA-binding protein that operates a translational switch in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

8 April 2019

Mitochondrial dysfunction reveals the role of mRNA poly(A) tail regulation in oculopharyngeal muscular dystrophy pathogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

nuclear-transcribed mRNA poly(A) tail shortening

biological process

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

1 reference

8 April 2019

regulation of translation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

1 reference

8 April 2019

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

1 reference

8 April 2019

establishment of RNA localization

1 reference

8 April 2019

Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

1 reference

8 April 2019

Mitochondrial dysfunction reveals the role of mRNA poly(A) tail regulation in oculopharyngeal muscular dystrophy pathogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

negative regulation of translation

Translational regulation and RNA localization in Drosophila oocytes and embryos.

5 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q23972&geneProductId=UniProtKB:Q23972

31 January 2018

SAM domains: uniform structure, diversity of function

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q23972&geneProductId=UniProtKB:Q23972

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q23972&geneProductId=UniProtKB:Q23972

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q23972&geneProductId=UniProtKB:Q23972

31 January 2018

31 January 2018

Smaug, a novel RNA-binding protein that operates a translational switch in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q23972&geneProductId=UniProtKB:Q23972

nuclear-transcribed mRNA poly(A) tail shortening

Oskar allows nanos mRNA translation in Drosophila embryos by preventing its deadenylation by Smaug/CCR4.

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

8 April 2019

Rapid ATP-dependent deadenylation of nanos mRNA in a cell-free system from Drosophila embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

negative regulation of translation

SAM domains: uniform structure, diversity of function

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

8 April 2019

Translational regulation and RNA localization in Drosophila oocytes and embryos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

8 April 2019

8 April 2019

Smaug, a novel RNA-binding protein that operates a translational switch in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

regulation of mRNA stability

SMAUG is a major regulator of maternal mRNA destabilization in Drosophila and its translation is activated by the PAN GU kinase.

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q23972

Smaug, PHAT analogous topology

has part(s)

1 reference

sterile alpha motif domain

1 reference

Protein Smaug, SAM domain

1 reference