(Q29819552)

English

Rhomboid Dmel_CG1004

Protein found in Drosophila melanogaster

rhomboid 1
rho-PB
rho-PA
rhomboid
rho
rhomboid/veinlet
rhomboid1
CG1004-PA
CG1004-PB
CG1004 gene product from transcript CG1004-RB
rhomboid-1
Rhomboid-I
veinlet

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

serine-type endopeptidase activity

determination method

12 references

8 April 2019

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

8 April 2019

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

8 April 2019

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

8 April 2019

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

8 April 2019

Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

8 April 2019

Rhomboid cleaves Star to regulate the levels of secreted Spitz

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

8 April 2019

Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic rhomboids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

8 April 2019

Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

8 April 2019

Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

8 April 2019

Generation of distinct signaling modes via diversification of the Egfr ligand-processing cassette.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

8 April 2019

A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

peptidase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

serine-type peptidase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

hydrolase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

serine-type endopeptidase activity

determination method

13 references

9 May 2019

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

9 May 2019

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

9 May 2019

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

9 May 2019

Rhomboid cleaves Star to regulate the levels of secreted Spitz

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

9 May 2019

Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

9 May 2019

Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

9 May 2019

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

9 May 2019

Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic rhomboids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

9 May 2019

Generation of distinct signaling modes via diversification of the Egfr ligand-processing cassette.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

9 May 2019

Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

9 May 2019

A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

integral component of membrane

determination method

apical part of cell

determination method

1 reference

9 May 2019

Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

late endosome membrane

determination method

1 reference

9 May 2019

Rhomboid cleaves Star to regulate the levels of secreted Spitz

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

determination method

1 reference

9 May 2019

A genome-wide resource for the analysis of protein localisation in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

biological process

mitotic cytokinesis

determination method

1 reference

9 May 2019

Molecular requirements for actin-based lamella formation in Drosophila S2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

morphogenesis of a branching structure

determination method

1 reference

27 February 2018

Genetic control of branching morphogenesis during Drosophila tracheal development.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

determination method

2 references

epidermal growth factor receptor signaling pathway

determination method

1 reference

27 February 2018

Localized activation of RTK/MAPK pathways during Drosophila development.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

multicellular organism development

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

determination method

1 reference

9 May 2019

Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

determination method

1 reference

9 May 2019

Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

brain development

determination method

1 reference

9 May 2019

A function for Egf receptor signaling in expanding the developing brain in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

peripheral nervous system development

determination method

1 reference

27 February 2018

Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

open tracheal system development

determination method

5 references

27 February 2018

Organ formation in Drosophila: specification and morphogenesis of the salivary gland.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

27 February 2018

Drosophila tracheal morphogenesis: intricate cellular solutions to basic plumbing problems

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

27 February 2018

Tube morphogenesis: closure, but many openings remain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

27 February 2018

Branching morphogenesis of the Drosophila tracheal system.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

27 February 2018

Genetic control of branching morphogenesis during Drosophila tracheal development.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

salivary gland development

determination method

1 reference

27 February 2018

Constructing an organ: the Drosophila salivary gland as a model for tube formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

salivary gland boundary specification

determination method

1 reference

27 February 2018

Organ formation in Drosophila: specification and morphogenesis of the salivary gland.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

larval salivary gland morphogenesis

determination method

1 reference

9 May 2019

A targeted gain-of-function screen identifies genes affecting salivary gland morphogenesis/tubulogenesis in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

imaginal disc-derived wing vein specification

determination method

4 references

27 February 2018

Blistered: a gene required for vein/intervein formation in wings of Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

27 February 2018

Pattern formation in the Drosophila wing: The development of the veins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

27 February 2018

MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

27 February 2018

Regulation of Drosophila wing vein patterning: net encodes a bHLH protein repressing rhomboid and is repressed by rhomboid-dependent Egfr signalling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

imaginal disc-derived wing morphogenesis

determination method

1 reference

9 May 2019

Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

leg disc proximal/distal pattern formation

determination method

1 reference

27 February 2018

Developmental biology: signalling legacies.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

imaginal disc-derived wing vein morphogenesis

determination method

3 references

9 May 2019

High mobility group proteins HMGD and HMGZ interact genetically with the Brahma chromatin remodeling complex in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

9 May 2019

Long-range Dpp signaling is regulated to restrict BMP signaling to a crossvein competent zone.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

9 May 2019

MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

positive regulation of gene expression

determination method

1 reference

9 May 2019

Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

ovarian follicle cell development

determination method

1 reference

27 February 2018

Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

maintenance of epithelial integrity, open tracheal system

determination method

1 reference

9 May 2019

Egfr is essential for maintaining epithelial integrity during tracheal remodelling in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

determination of genital disc primordium

determination method

1 reference

9 May 2019

Allocation and specification of the genital disc precursor cells in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

wing cell fate specification

determination method

1 reference

9 May 2019

MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

regulation of epidermal growth factor receptor signaling pathway

determination method

1 reference

9 May 2019

Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

positive regulation of phosphorylation

determination method

1 reference

9 May 2019

Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

positive regulation of epidermal growth factor receptor signaling pathway

determination method

1 reference

27 February 2018

The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

branched duct epithelial cell fate determination, open tracheal system

determination method

1 reference

27 February 2018

Cell fate choices in Drosophila tracheal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20350&geneProductId=UniProtKB:P20350

determination method

stem cell fate commitment

determination method

1 reference

9 May 2019

Drosophila adult muscle precursors form a network of interconnected cells and are specified by the rhomboid-triggered EGF pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

epithelial cell proliferation involved in Malpighian tubule morphogenesis

determination method

1 reference

9 May 2019

Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

cell-cell adhesion

determination method

1 reference

9 May 2019

Egfr is essential for maintaining epithelial integrity during tracheal remodelling in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

compound eye photoreceptor fate commitment

determination method

1 reference

9 May 2019

A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

imaginal disc-derived wing vein specification

determination method

3 references

9 May 2019

rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

9 May 2019

MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

9 May 2019

Regulation of Drosophila wing vein patterning: net encodes a bHLH protein repressing rhomboid and is repressed by rhomboid-dependent Egfr signalling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

leg disc proximal/distal pattern formation

determination method

1 reference

9 May 2019

Dynamic EGFR-Ras signalling in Drosophila leg development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

tracheal pit formation in open tracheal system

determination method

1 reference

9 May 2019

The RhoGAP crossveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invagination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

photoreceptor cell fate determination

determination method

1 reference

9 May 2019

The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

negative regulation of intracellular protein transport

determination method

1 reference

9 May 2019

Rhomboid cleaves Star to regulate the levels of secreted Spitz

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20350

determination method

Peptidase S54, rhomboid domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20350

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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