(Q29819759)

English

Roughoid Dmel_CG1214

Protein found in Drosophila melanogaster

roughoid/rhomboid-3
CG1214 gene product from transcript CG1214-RA
ru
roughoid
rhomboid
rhomboid3
CG1214-PA
ru-PA
rhomboid 3
Rhomboid-3

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Rhomboid-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9W0F8

Peptidase S54, rhomboid, metazoan

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9W0F8

Peptidase S54, rhomboid domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

hydrolase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

serine-type endopeptidase activity

determination method

5 references

9 May 2019

Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

9 May 2019

Rhomboid cleaves Star to regulate the levels of secreted Spitz

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

9 May 2019

A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

serine-type endopeptidase activity

determination method

4 references

8 April 2019

Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

8 April 2019

Rhomboid cleaves Star to regulate the levels of secreted Spitz

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

8 April 2019

A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

endoplasmic reticulum

determination method

1 reference

9 May 2019

Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

integral component of plasma membrane

determination method

1 reference

9 May 2019

A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

integral component of membrane

determination method

apical part of cell

determination method

1 reference

9 May 2019

Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

integral component of Golgi membrane

determination method

1 reference

9 May 2019

A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

late endosome membrane

determination method

1 reference

9 May 2019

Rhomboid cleaves Star to regulate the levels of secreted Spitz

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

biological process

compound eye morphogenesis

determination method

1 reference

9 May 2019

Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

compound eye photoreceptor fate commitment

determination method

1 reference

9 May 2019

A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

determination method

1 reference

9 May 2019

Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

epithelial cell migration, open tracheal system

determination method

1 reference

9 May 2019

Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

leg disc proximal/distal pattern formation

determination method

1 reference

9 May 2019

Developmental biology: signalling legacies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

protein processing

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9W0F8&geneProductId=UniProtKB:Q9W0F8

determination method

compound eye cone cell fate commitment

determination method

1 reference

9 May 2019

A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

adult chitin-containing cuticle pigmentation

determination method

1 reference

16 July 2018

Genetic Architecture of Abdominal Pigmentation in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9W0F8&geneProductId=UniProtKB:Q9W0F8

determination method

positive regulation of protein secretion

determination method

1 reference

9 May 2019

Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

determination method

determination method

1 reference

9 May 2019

A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9W0F8

determination method

Peptidase S54, rhomboid domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9W0F8

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

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