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Grim Dmel_CG4345
Protein found in Drosophila melanogaster
CG4345-PA
grim
grim-PA
CG4345 gene product from transcript CG4345-RA
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q24570
found in taxon
Drosophila melanogaster
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q24570
encoded by
grim
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q24570
molecular function
protein homodimerization activity
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
IPI
cell component
cytoplasm
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Drosophila grim induces apoptosis in mammalian cells.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
IDA
mitochondrion
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Drosophila grim induces apoptosis in mammalian cells.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
IDA
biological process
apoptotic process
determination method
IDA
IEA
IEP
IMP
NAS
TAS
6 references
retrieved
8 April 2019
stated in
Apoptosis. The little devil of death
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
NAS
retrieved
8 April 2019
stated in
grim, a novel cell death gene in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
IMP
retrieved
8 April 2019
stated in
grim, a novel cell death gene in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
IEP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q24570
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
IEA
retrieved
8 April 2019
stated in
The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
IDA
determination of adult lifespan
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
IMP
intrinsic apoptotic signaling pathway in response to osmotic stress
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Apoptotic proteins Reaper and Grim induce stable inactivation in voltage-gated K+ channels
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
TAS
programmed cell death involved in cell development
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Essential role of grim-led programmed cell death for the establishment of corazonin-producing peptidergic nervous system during embryogenesis and metamorphosis in Drosophila melanogaster
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
IMP
programmed cell death
determination method
TAS
2 references
retrieved
8 April 2019
stated in
Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
TAS
retrieved
8 April 2019
stated in
Death to flies: Drosophila as a model system to study programmed cell death
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
TAS
melanization defense response
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
IMP
larval central nervous system remodeling
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Metamorphosis in drosophila and other insects: the fate of neurons throughout the stages
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
TAS
positive regulation of apoptotic process
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
IMP
positive regulation of programmed cell death
determination method
IMP
2 references
retrieved
8 April 2019
stated in
grim promotes programmed cell death of Drosophila microchaete glial cells
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
IMP
retrieved
8 April 2019
stated in
Mechanisms of postecdysis-associated programmed cell death of peptidergic neurons in Drosophila melanogaster.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
IMP
negative regulation of neuron apoptotic process
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Coordinated expression of cell death genes regulates neuroblast apoptosis
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
IMP
nurse cell apoptotic process
determination method
TAS
2 references
retrieved
8 April 2019
stated in
Death to flies: Drosophila as a model system to study programmed cell death
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
TAS
retrieved
8 April 2019
stated in
Eggs to die for: cell death during Drosophila oogenesis
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
TAS
apoptotic signaling pathway
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
IGI
positive regulation of neuron death
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Mechanisms of postecdysis-associated programmed cell death of peptidergic neurons in Drosophila melanogaster.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
IMP
positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24570
determination method
IDA
Identifiers
RefSeq protein ID
NP_524137
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
40014
UniProt protein ID
Q24570
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q24570
Ensembl protein ID
FBpp0074896
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0074896
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