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Effete Dmel_CG7425
Protein found in Drosophila melanogaster
CG7425-PB
effette
suppressor of GMR-sina 3-3
ubiquitin conjugating enzyme 1
eff-PB
effete
eff
meiotic 68
CG7425 gene product from transcript CG7425-RC
eff-PA
CG7425-PA
CG7425-PC
eff-PC
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P25867
part of
Ubiquitin-conjugating enzyme/RWD-like
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P25867
Ubiquitin-conjugating enzyme E2 family
1 reference
based on heuristic
inferred from protein domain or family
Ubiquitin-conjugating enzyme, active site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Drosophila melanogaster
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P25867
encoded by
eff
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P25867
molecular function
nucleotide binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P25867
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IEA
protein binding
determination method
IPI
2 references
retrieved
8 April 2019
stated in
PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism.
GOA
curator
UniProt
UniProt protein ID
P25867
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IPI
retrieved
8 April 2019
stated in
PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IPI
ATP binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P25867
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IEA
transferase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P25867
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IEA
ubiquitin protein ligase binding
determination method
IPI
1 reference
retrieved
27 February 2018
stated in
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25867&geneProductId=UniProtKB:P25867
determination method
IPI
ubiquitin protein ligase activity
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IDA
ubiquitin conjugating enzyme activity
determination method
IDA
IGI
3 references
retrieved
27 February 2018
stated in
Drosophila UbcD1 encodes a highly conserved ubiquitin-conjugating enzyme involved in selective protein degradation
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25867&geneProductId=UniProtKB:P25867
determination method
IGI
retrieved
27 February 2018
stated in
Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25867&geneProductId=UniProtKB:P25867
determination method
IDA
retrieved
27 February 2018
stated in
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25867&geneProductId=UniProtKB:P25867
determination method
IDA
ubiquitin protein ligase binding
determination method
IBA
IPI
2 references
retrieved
8 April 2019
stated in
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IPI
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IBA
ubiquitin conjugating enzyme activity
determination method
IBA
IDA
IGI
4 references
retrieved
8 April 2019
stated in
Drosophila UbcD1 encodes a highly conserved ubiquitin-conjugating enzyme involved in selective protein degradation
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IGI
retrieved
8 April 2019
stated in
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IDA
retrieved
8 April 2019
stated in
Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IBA
cell component
cytosol
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
TAS
ubiquitin ligase complex
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IBA
biological process
protein polyubiquitination
determination method
IDA
IMP
2 references
retrieved
8 April 2019
stated in
Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IMP
retrieved
8 April 2019
stated in
Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IDA
mitotic cell cycle
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
UbcD1, a Drosophila ubiquitin-conjugating enzyme required for proper telomere behavior.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IMP
compound eye morphogenesis
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
A genetic screen to identify components of the sina signaling pathway in Drosophila eye development.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IMP
compound eye photoreceptor cell differentiation
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Phyllopod acts as an adaptor protein to link the sina ubiquitin ligase to the substrate protein tramtrack
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IMP
cell cycle
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P25867
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IEA
male meiotic nuclear division
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
UbcD1, a Drosophila ubiquitin-conjugating enzyme required for proper telomere behavior.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IMP
neuron remodeling
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Identification of E2/E3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IDA
protein ubiquitination
determination method
IDA
IEA
ISS
3 references
retrieved
8 April 2019
stated in
Drosophila UbcD1 encodes a highly conserved ubiquitin-conjugating enzyme involved in selective protein degradation
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P25867
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IEA
retrieved
8 April 2019
stated in
Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IDA
germ-line stem cell population maintenance
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IMP
anaphase-promoting complex-dependent catabolic process
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IMP
regulation of protein stability
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IMP
regulation of R7 cell differentiation
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
Phyllopod acts as an adaptor protein to link the sina ubiquitin ligase to the substrate protein tramtrack
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IGI
female germ-line stem cell asymmetric division
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IMP
chromosome organization
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
UbcD1, a Drosophila ubiquitin-conjugating enzyme required for proper telomere behavior.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IMP
cell division
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P25867
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IEA
meiosis
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P25867
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IEA
protein linear polyubiquitination
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IDA
ubiquitin-dependent protein catabolic process
determination method
IGI
IMP
2 references
retrieved
27 February 2018
stated in
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25867&geneProductId=UniProtKB:P25867
determination method
IMP
retrieved
27 February 2018
stated in
Drosophila UbcD1 encodes a highly conserved ubiquitin-conjugating enzyme involved in selective protein degradation
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P25867&geneProductId=UniProtKB:P25867
determination method
IGI
ubiquitin-dependent protein catabolic process
determination method
IBA
IGI
IMP
3 references
retrieved
8 April 2019
stated in
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IMP
retrieved
8 April 2019
stated in
Drosophila UbcD1 encodes a highly conserved ubiquitin-conjugating enzyme involved in selective protein degradation
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IGI
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IBA
negative regulation of smoothened signaling pathway
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25867
determination method
IMP
has part(s)
Ubiquitin-conjugating enzyme E2
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P25867
Ubiquitin-conjugating enzyme, active site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P25867
Identifiers
RefSeq protein ID
NP_001262578
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
41785
NP_001262579
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
41785
NP_731941
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
41785
UniProt protein ID
P25867
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P25867
Ensembl protein ID
FBpp0302691
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0302691
FBpp0307824
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0307824
FBpp0082477
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0082477
Sitelinks
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Wikibooks
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Wikinews
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Wikiquote
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Wikisource
(0 entries)
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Wikiversity
(0 entries)
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Wikivoyage
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Wiktionary
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Multilingual sites
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