(Q29821019)

English

PTEN-induced putative kinase 1 Dmel_CG4523

Protein found in Drosophila melanogaster

Pink1-PI
PINK1
CG4523-PF
Pink1-PD
Pink1-PG
PTEN induced putative kinase 1
CG4523-PG
Pink1-PE
PTEN-induced kinase 1
CG4523-PI
CG4523-PE
phosphatase and tensin homolog-induced putative kinase 1
CG4523-PA
pink
PTEN-induced putative kinase 1
Pink1-PA
Pink1-PC
Pink1-PF
CG4523-PH
CG4523-PC
Pink1-PH
CG4523-PD
Pink1-PB
CG4523 gene product from transcript CG4523-RH
CG4523-PB

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Statements

1 reference

25 May 2022

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

protein serine/threonine kinase activity

1 reference

27 February 2018

PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q0KHV6&geneProductId=UniProtKB:Q0KHV6

3 references

8 April 2019

PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IEA

protein kinase activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IBA

protein serine/threonine kinase activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IBA

ATP-dependent protein binding

1 reference

8 April 2019

PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

1 reference

8 April 2019

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

1 reference

27 February 2018

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q0KHV6&geneProductId=UniProtKB:Q0KHV6

1 reference

8 April 2019

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

3 references

8 April 2019

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

1 reference

8 April 2019

PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IDA

biological process

autophagy of mitochondrion

1 reference

27 February 2018

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q0KHV6&geneProductId=UniProtKB:Q0KHV6

determination method

IMP

response to oxidative stress

1 reference

8 April 2019

Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IMP

mitochondrion organization

9 references

8 April 2019

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

The PINK1/Parkin pathway regulates mitochondrial morphology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IDA

neuromuscular synaptic transmission

1 reference

8 April 2019

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IMP

negative regulation of mitochondrial fusion

1 reference

8 April 2019

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IMP

regulation of mitochondrion organization

1 reference

8 April 2019

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IEA

sperm mitochondrion organization

3 references

8 April 2019

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IMP

ectopic germ cell programmed cell death

1 reference

8 April 2019

Alternative germ cell death pathway in Drosophila involves HtrA2/Omi, lysosomes, and a caspase-9 counterpart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IMP

negative regulation of programmed cell death

1 reference

8 April 2019

Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IMP

negative regulation of neuron apoptotic process

1 reference

8 April 2019

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IDA

mitochondrion transport along microtubule

1 reference

8 April 2019

Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IMP

positive regulation of compound eye pigmentation

1 reference

8 April 2019

Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IMP

intracellular distribution of mitochondria

1 reference

8 April 2019

Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IMP

compound eye development

1 reference

8 April 2019

Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IMP

establishment of mitochondrion localization

1 reference

8 April 2019

Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IMP

positive regulation of mitochondrial fission

1 reference

27 February 2018

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q0KHV6&geneProductId=UniProtKB:Q0KHV6

determination method

IMP

ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IMP

protein phosphorylation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IBA

autophagy of mitochondrion

3 references

8 April 2019

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

1 reference

8 April 2019

Drosophila PINK1 and parkin loss-of-function mutants display a range of non-motor Parkinson's disease phenotypes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

1 reference

8 April 2019

Drosophila PINK1 and parkin loss-of-function mutants display a range of non-motor Parkinson's disease phenotypes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IMP

positive regulation of locomotor rhythm

1 reference

8 April 2019

Drosophila PINK1 and parkin loss-of-function mutants display a range of non-motor Parkinson's disease phenotypes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IMP

positive regulation of neuronal action potential

1 reference

8 April 2019

Drosophila PINK1 and parkin loss-of-function mutants display a range of non-motor Parkinson's disease phenotypes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q0KHV6

determination method

IMP

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

(Q29821019)

PTEN-induced putative kinase 1 Dmel_CG4523

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