(Q29938716)

English

ABL1 BCR::ABL V299L

genetic variant

V299L
V318L
VAL299LEU
BCR-ABL V299L
BCR-ABL VAL299LEU
BCR-ABL V318L
RS1057519771
BCR-ABL1 V299L
BCR-ABL1 VAL299LEU
BCR::ABL V299L

In more languages

default values for all languages

No label defined

No description defined

Statements

missense mutation

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1231

transcript fusion

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1231

human chromosome 9

genomic assembly

Genome assembly GRCh37

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1231

133747588

genomic assembly

Genome assembly GRCh37

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1231

133747588

genomic assembly

Genome assembly GRCh37

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1231

biological variant of

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1231

positive therapeutic predictor for

medical condition treated

chronic myeloid leukemia

determination method

CIViC evidence level D

CIViC 3-star trust rating

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/2862

Activity of bosutinib, dasatinib, and nilotinib against 18 imatinib-resistant BCR/ABL mutants

determination method

CIViC evidence level D

CIViC 2-star trust rating

medical condition treated

chronic myeloid leukemia

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/7767

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

negative therapeutic predictor for

dasatinib monohydrate

determination method

CIViC evidence level C

CIViC 1-star trust rating

medical condition treated

chronic myeloid leukemia

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/4540

Dasatinib treatment of chronic-phase chronic myeloid leukemia: analysis of responses according to preexisting BCR-ABL mutations

dasatinib monohydrate

determination method

CIViC evidence level D

CIViC 3-star trust rating

medical condition treated

chronic myeloid leukemia

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/6216

Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance

dasatinib monohydrate / imatinib mesylate combination therapy

determination method

CIViC evidence level D

CIViC 2-star trust rating

medical condition treated

chronic myeloid leukemia

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/6241

Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: high efficacy of drug combinations

dasatinib monohydrate

determination method

CIViC evidence level D

CIViC 2-star trust rating

medical condition treated

chronic myeloid leukemia

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/6247

Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: high efficacy of drug combinations

imatinib mesylate

determination method

CIViC evidence level B

CIViC 1-star trust rating

medical condition treated

chronic myeloid leukemia

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/6982

Bosutinib is active in chronic phase chronic myeloid leukemia after imatinib and dasatinib and/or nilotinib therapy failure

Identifiers

CIViC variant ID

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1231

dbSNP Reference SNP number

1 reference

HGVS nomenclature

NM_005157.5:c.895G>C

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1231

NP_005148.2:p.Val299Leu

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1231

NC_000009.11:g.133747588G>C

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1231

ENST00000318560.5:c.895G>C

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1231

Sitelinks

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Wikisource(0 entries)

Wikiversity(0 entries)

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Wiktionary(0 entries)

Multilingual sites(0 entries)

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