(Q29971817)

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Vitamin D (calciferol) metabolism

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-196791)

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8 July 2022

vitamin D metabolic process

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Metabolism of steroids

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https://identifiers.org/reactome:R-HSA-196791

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Photolytic cleavage and thermal isomerization of 7-dehydroCHOL

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VD3 translocates from ER membrane to extracellular region

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VD3 translocates from extracellular region to ER membrane

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VD3 dissociates from GC

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CYP2R1 25-hydroxylates VD3 to 25(OH)D

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25(OH)D translocates from ER membrane to extracellular region

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CUBN binds GC:25(OH)D

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LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D

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Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen

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CUBN dissociates from 25(OH)D

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25(OH)D translocates from lysosomal lumen to cytosol

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CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D

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CYP24A1 hydroxylates 1,25(OH)2D, inactivating it

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1,25(OH)2D translocates from cytosol to nucleoplasm

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PIAS4 SUMOylates VDR with SUMO2

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VDR agonists bind VDR

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Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.

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Identifiers

1 reference

8 July 2022

(Q29971817)

Vitamin D (calciferol) metabolism

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