(Q3271551)

Frizzled cysteine-rich domain superfamily

1 reference

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.16.4

2 October 2019

hierarchical database ID heuristic

Frizzled/Smoothened, transmembrane domain, protein family

1 reference

inferred from protein domain or family

GPCR, family 2-like

1 reference

inferred from protein domain or family

Frizzled domain, protein family

1 reference

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

26 September 2017

Characterization of two patched receptors for the vertebrate hedgehog protein family

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

1 reference

26 September 2017

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

transmembrane signaling receptor activity

IPI

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

signal transducer activity

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

Wnt-activated receptor activity

IBA

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

endocytic vesicle membrane

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

2 references

1 reference

26 September 2017

The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

1 reference

26 September 2017

The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

intracellular membrane-bounded organelle

IDA

1 reference

26 September 2017

The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

4 references

26 September 2017

The hedgehog receptor patched is involved in cholesterol transport

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

integral component of membrane

3 references

pattern specification process

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

pancreas morphogenesis

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

smoothened signaling pathway involved in ventral spinal cord patterning

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

odontogenesis of dentin-containing tooth

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

atrial septum morphogenesis

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

cell surface receptor signaling pathway

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

positive regulation of mesenchymal cell proliferation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

cerebellar cortex morphogenesis

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

positive regulation of multicellular organism growth

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

hair follicle morphogenesis

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

type B pancreatic cell development

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

positive regulation of neuroblast proliferation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development

renal system development

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

positive regulation of smoothened signaling pathway

IEP

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

embryonic organ development

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

dentate gyrus development

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

epithelial-mesenchymal cell signaling

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

regulation of stem cell population maintenance

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

in utero embryonic development

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

positive regulation of transcription, DNA-templated

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

negative regulation of hair follicle development

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

central nervous system development

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

central nervous system neuron differentiation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

positive regulation of protein import into nucleus

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

smoothened signaling pathway

6 references

26 September 2017

Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

26 September 2017

Evidence for allosteric interactions of antagonist binding to the smoothened receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

26 September 2017

Activating Smoothened mutations in sporadic basal-cell carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

26 September 2017

Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

G protein-coupled receptor signaling pathway

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

multicellular organism growth

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

positive regulation of epithelial cell proliferation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

cell fate specification

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

protein stabilization

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

positive regulation of organ growth

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

negative regulation of apoptotic process

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

negative regulation of transcription by RNA polymerase II

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

osteoblast differentiation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

cerebral cortex development

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

regulation of gene expression

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

homeostasis of number of cells within a tissue

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

dorsal/ventral neural tube patterning

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

negative regulation of transcription, DNA-templated

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

dorsal/ventral pattern formation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

mammary gland epithelial cell differentiation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

multicellular organism development

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

determination of left/right symmetry

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

skeletal muscle fiber development

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

neural crest cell migration

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

positive regulation of cell population proliferation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

protein localization to nucleus

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

digestive tract development

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

negative regulation of epithelial cell differentiation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

left/right axis specification

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

anterior/posterior pattern specification

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

positive regulation of transcription by RNA polymerase II

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

non-canonical Wnt signaling pathway

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

canonical Wnt signaling pathway

IBA

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835

physically interacts with

IBA

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

8198

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

8199

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

6975

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL538867

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL473417

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2105737

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3545403

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2043437

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2205230

Gene Atlas image

PBB GE SMO 218629 at fs.png
732 × 530; 12 KB

0 references

has part(s)

frizzled domain

1 reference

GPCR, family 2-like

1 reference

Frizzled/Smoothened, transmembrane domain

1 reference

Identifiers

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

English

9.A.14.16.4

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023