(Q32965008)

English

ABL1 BCR::ABL F359I

genetic variant

F359I
BCR-ABL F359I
RS121913452
F378I
PHE359ILE
BCR-ABL PHE359ILE
BCR-ABL1 F359I
BCR-ABL1 PHE359ILE
BCR::ABL F359I

In more languages

default for all languages

No label defined

No description defined

Statements

missense mutation

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1523

transcript fusion

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1523

human chromosome 9

genomic assembly

Genome assembly GRCh37

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1523

133748414

genomic assembly

Genome assembly GRCh37

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1523

133748414

genomic assembly

Genome assembly GRCh37

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1523

biological variant of

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1523

negative therapeutic predictor for

determination method

CIViC evidence level C

CIViC 2-star trust rating

medical condition treated

chronic myeloid leukemia

statement disputed by

Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/4530

Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib

dasatinib monohydrate

determination method

CIViC evidence level B

CIViC 3-star trust rating

medical condition treated

chronic myeloid leukemia

statement disputed by

Dasatinib treatment of chronic-phase chronic myeloid leukemia: analysis of responses according to preexisting BCR-ABL mutations

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/4532

Dasatinib treatment of chronic-phase chronic myeloid leukemia: analysis of responses according to preexisting BCR-ABL mutations

determination method

CIViC evidence level C

CIViC 2-star trust rating

medical condition treated

chronic myeloid leukemia

statement disputed by

Bosutinib is active in chronic phase chronic myeloid leukemia after imatinib and dasatinib and/or nilotinib therapy failure

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/4531

Bosutinib is active in chronic phase chronic myeloid leukemia after imatinib and dasatinib and/or nilotinib therapy failure

imatinib mesylate

determination method

CIViC evidence level C

CIViC 1-star trust rating

medical condition treated

chronic myeloid leukemia

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/6984

Bosutinib is active in chronic phase chronic myeloid leukemia after imatinib and dasatinib and/or nilotinib therapy failure

determination method

CIViC evidence level D

CIViC 2-star trust rating

medical condition treated

chronic myeloid leukemia

statement disputed by

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/4529

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

dasatinib monohydrate

determination method

CIViC evidence level C

CIViC 3-star trust rating

medical condition treated

chronic myeloid leukemia

statement disputed by

Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/evidence/4533

Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias

Identifiers

CIViC variant ID

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1523

dbSNP Reference SNP number

1 reference

HGVS nomenclature

NM_005157.5:c.1075T>A

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1523

NP_005148.2:p.Phe359Ile

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1523

NC_000009.11:g.133748414T>A

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1523

ENST00000318560.5:c.1075T>A

1 reference

28 March 2022

https://civic.genome.wustl.edu/links/variants/1523

Sitelinks

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