(Q34340150)

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Cholesterol biosynthesis

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-191273)

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cholesterol biosynthetic process

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Metabolism of steroids

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https://identifiers.org/reactome:R-HSA-191273

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Cholesterol biosynthesis via desmosterol

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Cholesterol biosynthesis via lathosterol

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ACAT2 condenses 2 Ac-CoA to form ACA-CoA

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HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA

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HMGCR dimer reduces bHMG-CoA to MVA

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Mevalonate is phosphorylated to mevalonate-5-phosphate

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Mevalonate-5-phosphate is further phosphorylated.

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MVD decarboxylates MVA5PP to IPPP

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Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate

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FDPS dimer transfers IPPP to DMAPP

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FDPS dimer transfers IPPP to GPP

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Two FPP molecules dimerize to form presqualene diphosphate

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Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate

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Reduction of presqualene diphosphate to form squalene

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Squalene is oxidized to its epoxide

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Squalene 2,3-epoxide cyclizes, forming lanosterol

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CYP51A1 demethylates LNSOL

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4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]

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4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol

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4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one

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4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol

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4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]

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4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol

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4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)

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Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol)

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ARV1 transports CHOL from ER membrane to plasma membrane

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holo-FDPS dimer binds NBPs

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GGPS1 hexamer transfers IPPP to GPP

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GGPS1 hexamer transfers IPPP to DMAPP

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HMGCR dimer binds statins

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DHCR24 reduces LAN to 24,25-dhLAN

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Cholesterol biosynthesis and metabolism

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Membrane-bound enzymes of cholesterol synthesis from lanosterol

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Regulation of cholesterol biosynthesis

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Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol

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Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes

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Identifiers

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(Q34340150)

Cholesterol biosynthesis

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