(Q3445743)

English

Apolipoprotein C2

mammalian protein found in Homo sapiens

APOC2
apolipoprotein C-II

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Apolipoprotein C-II

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02655

ApoC-II domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02655

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

lipase inhibitor activity

determination method

1 reference

8 April 2019

Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

phospholipase binding

determination method

1 reference

27 March 2018

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02655&geneProductId=UniProtKB:P02655

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Identification of disulfide-linked apolipoprotein species in human lipoproteins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

lipoprotein lipase activator activity

determination method

phospholipase activator activity

determination method

1 reference

27 March 2018

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02655&geneProductId=UniProtKB:P02655

determination method

enzyme activator activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

determination method

1 reference

27 March 2018

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02655&geneProductId=UniProtKB:P02655

determination method

lipoprotein lipase activator activity

determination method

3 references

8 April 2019

Activation of lipoprotein lipase by native and synthetic fragments of human plasma apolipoprotein C-II

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

8 April 2019

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

determination method

3 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02655&geneProductId=UniProtKB:P02655

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02655&geneProductId=UniProtKB:P02655

determination method

27 March 2018

Identification of disulfide-linked apolipoprotein species in human lipoproteins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02655&geneProductId=UniProtKB:P02655

determination method

spherical high-density lipoprotein particle

determination method

1 reference

27 March 2018

Isolation and characterization of human apolipoprotein M-containing lipoproteins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02655&geneProductId=UniProtKB:P02655

determination method

extracellular region

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

8 April 2019

The human plasma proteome: a nonredundant list developed by combination of four separate sources

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

high-density lipoprotein particle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

intermediate-density lipoprotein particle

determination method

1 reference

27 March 2018

Fractionation of cholesteryl ester rich intermediate density lipoprotein subpopulations by chondroitin sulphate

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02655&geneProductId=UniProtKB:P02655

determination method

extracellular space

determination method

1 reference

8 April 2019

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

very-low-density lipoprotein particle

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

8 April 2019

Identification of disulfide-linked apolipoprotein species in human lipoproteins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

low-density lipoprotein particle

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

8 April 2019

Identification of disulfide-linked apolipoprotein species in human lipoproteins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

8 April 2019

Identification of disulfide-linked apolipoprotein species in human lipoproteins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

biological process

high-density lipoprotein particle clearance

determination method

1 reference

27 March 2018

Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02655&geneProductId=UniProtKB:P02655

determination method

positive regulation of triglyceride catabolic process

determination method

1 reference

8 April 2019

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

chylomicron remnant clearance

determination method

1 reference

27 March 2018

Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02655&geneProductId=UniProtKB:P02655

determination method

phospholipid efflux

determination method

1 reference

8 April 2019

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

positive regulation of fatty acid biosynthetic process

determination method

1 reference

8 April 2019

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

negative regulation of very-low-density lipoprotein particle clearance

determination method

1 reference

27 March 2018

Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02655&geneProductId=UniProtKB:P02655

determination method

retinoid metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

negative regulation of receptor-mediated endocytosis

determination method

1 reference

8 April 2019

Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

lipid catabolic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

positive regulation of phospholipase activity

determination method

1 reference

27 March 2018

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02655&geneProductId=UniProtKB:P02655

determination method

positive regulation of phospholipid catabolic process

determination method

1 reference

27 March 2018

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02655&geneProductId=UniProtKB:P02655

determination method

cholesterol efflux

determination method

1 reference

8 April 2019

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

very-low-density lipoprotein particle remodeling

determination method

1 reference

8 April 2019

Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

negative regulation of cholesterol transport

determination method

1 reference

8 April 2019

Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

cholesterol homeostasis

determination method

1 reference

8 April 2019

Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

positive regulation of very-low-density lipoprotein particle remodeling

determination method

1 reference

8 April 2019

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

triglyceride-rich lipoprotein particle remodeling

determination method

1 reference

8 April 2019

Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

triglyceride homeostasis

determination method

1 reference

8 April 2019

Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

negative regulation of lipid metabolic process

determination method

1 reference

8 April 2019

Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

reverse cholesterol transport

determination method

1 reference

8 April 2019

Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

negative regulation of catalytic activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

lipoprotein transport

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

high-density lipoprotein particle remodeling

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

chylomicron assembly

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

negative regulation of very-low-density lipoprotein particle clearance

determination method

chylomicron remnant clearance

determination method

positive regulation of lipoprotein lipase activity

determination method

3 references

8 April 2019

Apolipoprotein A-V-heparin interactions: implications for plasma lipoprotein metabolism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

8 April 2019

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02655

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000252490

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000252490

ENSP00000465001

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465001

ENSP00000466775

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000466775

ENSP00000477261

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000477261

ENSP00000476835

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000476835

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

ScienceDirect topic ID

agricultural-and-biological-sciences/apolipoprotein-c-ii

0 references

Sitelinks

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