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CHEK2 phosphorylates TP53
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-69685)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-69685
part of
Stabilization of p53
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-69685
Regulation of TP53 Activity through Phosphorylation
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-69685
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-69685
exact match
https://identifiers.org/reactome:R-HSA-69685
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-69685
has part(s)
ATP(4-)
quantity
4
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-69685
p-S15-TP53 Tetramer [nucleoplasm]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-69685
ADP(3-)
quantity
4
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-69685
p-S15,S20-TP53 Tetramer [nucleoplasm]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-69685
p-S,3T-CHEK2 [nucleoplasm]
quantity
1
object has role
modifier
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-69685
cites work
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-69685
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-69685
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-69685
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-69685
Identifiers
Reactome ID
R-HSA-69685
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-69685
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