(Q36811954)

English

CHEK2 is recruited to DNA DSBs

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-5683735)

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Statements

biological process

1 reference

8 July 2022

G2/M DNA damage checkpoint

1 reference

8 July 2022

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-5683735

1 reference

8 July 2022

checkpoint kinase 2

1

object has role

1 reference

8 July 2022

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm]

1

object has role

1 reference

8 July 2022

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucl...

1

object has role

1 reference

8 July 2022

53BP1, a mediator of the DNA damage checkpoint

1 reference

8 July 2022

NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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