(Q37753078)

English

NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-2730752)

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1 reference

8 July 2022

Constitutive Signaling by NOTCH1 HD Domain Mutants

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-2730752

1 reference

8 July 2022

NOTCH1 HD domain mutants/Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane]

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1 reference

8 July 2022

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8 July 2022

NOTCH1 HD domain mutant fragments/Ub-DLL/JAG:NOTCH1 HD domain mutant fragments [extracellular region]

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1 reference

8 July 2022

ADAM10/17:Zn2+ [plasma membrane]

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1 reference

8 July 2022

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

1 reference

8 July 2022

Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

1 reference

8 July 2022

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

1 reference

8 July 2022

Structural basis for autoinhibition of Notch

1 reference

8 July 2022

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.

1 reference

8 July 2022

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q37753078)

NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding

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