(Q3822573)

Concanavalin A-like lectin/glucanase domain superfamily

1 reference

Thrombospondin type-1 (TSP1) repeat superfamily

1 reference

thrombospondin-1

1 reference

Thrombospondin, C-terminal domain, protein family

1 reference

Laminin G domain, protein family

1 reference

VWFC domain, protein family

1 reference

EGF-like calcium-binding domain, protein family

1 reference

EGF-like domain, protein family

1 reference

Thrombospondin, type 3-like repeat, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

Thrombospondin type-1 (TSP1) repeat, protein family

1 reference

Thrombospondin, type 3 repeat, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 reference

13 November 2019

1 reference

13 November 2019

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Thrombospondin 3 is a developmentally regulated heparin binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Isolation and characterization of a high molecular weight glycoprotein from human blood platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

extracellular matrix binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

fibroblast growth factor binding

1 reference

8 April 2019

Fibroblast growth factor-2 binding to the thrombospondin-1 type III repeats, a novel antiangiogenic domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

phosphatidylserine binding

1 reference

8 April 2019

Phosphatidylserine-positive erythrocytes bind to immobilized and soluble thrombospondin-1 via its heparin-binding domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 reference

8 April 2019

Interactions of thrombospondin with extracellular matrix proteins: selective binding to type V collagen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 reference

8 April 2019

Interactions of thrombospondin with extracellular matrix proteins: selective binding to type V collagen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

low-density lipoprotein particle binding

1 reference

8 April 2019

Interactions of thrombospondin with extracellular matrix proteins: selective binding to type V collagen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 reference

8 April 2019

Interactions of thrombospondin with extracellular matrix proteins: selective binding to type V collagen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 reference

8 April 2019

Interactions of thrombospondin with extracellular matrix proteins: selective binding to type V collagen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

identical protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

transforming growth factor beta binding

NAS

11 references

8 April 2019

Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Calumenin but not reticulocalbin forms a Ca2+-dependent complex with thrombospondin-1. A potential role in haemostasis and thrombosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

The first draft of the endostatin interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

TSG-6 binds via its CUB_C domain to the cell-binding domain of fibronectin and increases fibronectin matrix assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Extended interaction network of procollagen C-proteinase enhancer-1 in the extracellular matrix

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Complex formation of human thrombospondin with osteonectin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Insulin-like growth factor binding protein-5 (IGFBP-5) interacts with thrombospondin-1 to induce negative regulatory effects on IGF-I actions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Extracellular Fibrinogen-binding Protein (Efb) from Staphylococcus aureus Inhibits the Formation of Platelet-Leukocyte Complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

extracellular matrix structural constituent

IPI

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 January 2018

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 January 2018

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 January 2018

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 January 2018

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

extracellular matrix structural constituent

9 references

1 January 2018

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 January 2018

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 January 2018

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 January 2018

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 January 2018

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 January 2018

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 January 2018

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 January 2018

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

extracellular matrix structural constituent

5 references

8 April 2019

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

endoplasmic reticulum lumen

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets

platelet alpha granule

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

3 references

17 October 2017

Isolation of the thrombospondin membrane receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

Interaction of thrombospondin with resting and stimulated human platelets

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

extracellular exosome

5 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

Protein profile of exosomes from trabecular meshwork cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

5 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 reference

8 April 2019

Isolation and characterization of a high molecular weight glycoprotein from human blood platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

platelet alpha granule lumen

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 reference

8 April 2019

Incorporation of thrombospondin into fibrin clots

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

external side of plasma membrane

1 reference

8 April 2019

Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

6 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

Angiogenic microRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

7 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 January 2018

Angiogenic microRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 January 2018

Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 January 2018

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 January 2018

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Isolation of the thrombospondin membrane receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Interaction of thrombospondin with resting and stimulated human platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

collagen-containing extracellular matrix

7 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 January 2018

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 January 2018

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 January 2018

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 January 2018

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 January 2018

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 January 2018

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

extracellular exosome

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Protein profile of exosomes from trabecular meshwork cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Angiogenic microRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 reference

8 April 2019

Cultured human fibroblasts synthesize and secrete thrombospondin and incorporate it into extracellular matrix

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

collagen-containing extracellular matrix

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of transforming growth factor beta receptor signaling pathway

biological process

1 reference

8 April 2019

Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

cellular response to heat

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of fibrinolysis

NAS

1 reference

8 April 2019

Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

protein O-linked fucosylation

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

response to progesterone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

response to magnesium ion

1 reference

8 April 2019

Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of translation

1 reference

8 April 2019

Insulin-like growth factor binding protein-5 (IGFBP-5) interacts with thrombospondin-1 to induce negative regulatory effects on IGF-I actions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of endothelial cell migration

1 reference

8 April 2019

Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of long-chain fatty acid import across plasma membrane

1 reference

8 April 2019

Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of reactive oxygen species metabolic process

1 reference

8 April 2019

Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of blood coagulation

1 reference

8 April 2019

Incorporation of thrombospondin into fibrin clots

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of blood vessel endothelial cell migration

1 reference

8 April 2019

Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of macrophage chemotaxis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of protein kinase B signaling

ISS

1 reference

8 April 2019

Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of plasminogen activation

1 reference

8 April 2019

Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of blood vessel endothelial cell migration

1 reference

8 April 2019

Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of extrinsic apoptotic signaling pathway

1 reference

8 April 2019

Syndecan-4 contributes to endothelial tubulogenesis through interactions with two motifs inside the pro-angiogenic N-terminal domain of thrombospondin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

response to endoplasmic reticulum stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of endothelial cell apoptotic process

ISS

1 reference

8 April 2019

Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

response to unfolded protein

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of chemotaxis

1 reference

8 April 2019

Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of cGMP-mediated signaling

1 reference

8 April 2019

Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of phosphorylation

1 reference

8 April 2019

Interaction of alpha9beta1 integrin with thrombospondin-1 promotes angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of focal adhesion assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

chronic inflammatory response

1 reference

8 April 2019

Thrombospondin-1 and transforming growth factor beta are pro-inflammatory molecules in rheumatoid arthritis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

engulfment of apoptotic cell

IEP

1 reference

8 April 2019

Apoptotic cell thrombospondin-1 and heparin-binding domain lead to dendritic-cell phagocytic and tolerizing states

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

extracellular matrix organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of macrophage activation

1 reference

8 April 2019

Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

Syndecan-4 contributes to endothelial tubulogenesis through interactions with two motifs inside the pro-angiogenic N-terminal domain of thrombospondin-1

sprouting angiogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of apoptotic process

1 reference

8 April 2019

Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 reference

8 April 2019

Cell type-specific post-transcriptional regulation of production of the potent antiangiogenic and proatherogenic protein thrombospondin-1 by high glucose

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of transforming growth factor beta1 production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

behavioral response to pain

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 reference

8 April 2019

Thrombospondin-1 and transforming growth factor beta are pro-inflammatory molecules in rheumatoid arthritis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of interleukin-12 production

IEP

1 reference

8 April 2019

Apoptotic cell thrombospondin-1 and heparin-binding domain lead to dendritic-cell phagocytic and tolerizing states

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

1 reference

8 April 2019

Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of cell migration

NAS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

platelet degranulation

1 reference

8 April 2019

negative regulation of endothelial cell chemotaxis

1 reference

8 April 2019

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of endothelial cell proliferation

3 references

8 April 2019

Interaction of alpha9beta1 integrin with thrombospondin-1 promotes angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Fibroblast growth factor-2 binding to the thrombospondin-1 type III repeats, a novel antiangiogenic domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of endothelial cell migration

1 reference

8 April 2019

Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of fibroblast growth factor receptor signaling pathway

1 reference

8 April 2019

Fibroblast growth factor-2 binding to the thrombospondin-1 type III repeats, a novel antiangiogenic domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

Incorporation of thrombospondin into fibrin clots

peptide cross-linking

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

1 reference

8 April 2019

Apoptotic cell thrombospondin-1 and heparin-binding domain lead to dendritic-cell phagocytic and tolerizing states

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of dendritic cell antigen processing and presentation

1 reference

8 April 2019

Apoptotic cell thrombospondin-1 and heparin-binding domain lead to dendritic-cell phagocytic and tolerizing states

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of angiogenesis

6 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

Novel antiangiogenic pathway of thrombospondin-1 mediated by suppression of the cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

17 October 2017

Fibroblast growth factor-2 binding to the thrombospondin-1 type III repeats, a novel antiangiogenic domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 reference

8 April 2019

Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of fibroblast migration

1 reference

8 April 2019

Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

response to testosterone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

cellular response to tumor necrosis factor

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

cellular response to growth factor stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of transforming growth factor beta production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

response to mechanical stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of cell population proliferation

1 reference

8 April 2019

Interleukin-18 may lead to benign prostatic hyperplasia via thrombospondin-1 production in prostatic smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of smooth muscle cell proliferation

1 reference

8 April 2019

Interleukin-18 may lead to benign prostatic hyperplasia via thrombospondin-1 production in prostatic smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

regulation of megakaryocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

inflammatory response

3 references

1 January 2018

1 January 2018

Endogenous thrombospondin-1 regulates leukocyte recruitment and activation and accelerates death from systemic candidiasis

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07996&geneProductId=UniProtKB:P07996

negative regulation of angiogenesis

IBA

8 references

8 April 2019

MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Novel antiangiogenic pathway of thrombospondin-1 mediated by suppression of the cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Fibroblast growth factor-2 binding to the thrombospondin-1 type III repeats, a novel antiangiogenic domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

positive regulation of transforming growth factor beta receptor signaling pathway

IBA

IBA

negative regulation of cell migration involved in sprouting angiogenesis

1 reference

8 April 2019

miR-487b promotes human umbilical vein endothelial cell proliferation, migration, invasion and tube formation through regulating THBS1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

1 reference

8 April 2019

miR-487b promotes human umbilical vein endothelial cell proliferation, migration, invasion and tube formation through regulating THBS1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

negative regulation of sprouting angiogenesis

1 reference

8 April 2019

Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126-5p in control of endothelial cell function in angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07996

Thrombospondin type-1 (TSP1) repeat

IGI

Gene Atlas image

PBB GE THBS1 201110 s at fs.png
732 × 530; 11 KB

0 references

has part(s)

1 reference

EGF-like, conserved site

1 reference

Thrombospondin, C-terminal

1 reference

VWFC domain

1 reference

Thrombospondin, type 3 repeat

1 reference

Laminin G domain

1 reference

Thrombospondin, type 3-like repeat

1 reference

EGF-like domain

1 reference

EGF-like calcium-binding domain

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016