(Q4068038)

English

apolipoprotein C3

mammalian protein found in Homo sapiens

APOC3
apolipoprotein C-III

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

apolipoprotein CIII

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02656

Apolipoprotein CIII superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02656

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

lipase inhibitor activity

determination method

4 references

17 October 2017

Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

17 October 2017

Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

17 October 2017

Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

17 October 2017

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

enzyme regulator activity

determination method

1 reference

8 April 2019

Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

high-density lipoprotein particle receptor binding

determination method

1 reference

17 October 2017

Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

cholesterol binding

determination method

1 reference

8 April 2019

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

phospholipid binding

determination method

3 references

8 April 2019

Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

8 April 2019

Behavior of human apolipoprotein E in aqueous solutions and at interfaces

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

lipase inhibitor activity

determination method

5 references

8 April 2019

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

8 April 2019

Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

8 April 2019

Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

8 April 2019

Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

high-density lipoprotein particle receptor binding

determination method

very-low-density lipoprotein particle

determination method

4 references

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

17 October 2017

Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

17 October 2017

Apolipoprotein E enrichment of immuno-separated chylomicron and chylomicron remnants following saturated fatty acids

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

17 October 2017

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

spherical high-density lipoprotein particle

determination method

1 reference

17 October 2017

Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

extracellular exosome

determination method

intermediate-density lipoprotein particle

determination method

1 reference

17 October 2017

Fractionation of cholesteryl ester rich intermediate density lipoprotein subpopulations by chondroitin sulphate

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

extracellular space

determination method

1 reference

8 April 2019

Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

very-low-density lipoprotein particle

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

8 April 2019

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

8 April 2019

Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

8 April 2019

Apolipoprotein E enrichment of immuno-separated chylomicron and chylomicron remnants following saturated fatty acids

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

8 April 2019

Identification of disulfide-linked apolipoprotein species in human lipoproteins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

extracellular exosome

determination method

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

biological process

negative regulation of cholesterol import

determination method

1 reference

8 April 2019

Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

G protein-coupled receptor signaling pathway

determination method

1 reference

8 April 2019

Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

negative regulation of very-low-density lipoprotein particle remodeling

determination method

chylomicron remnant clearance

determination method

1 reference

8 April 2019

Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

negative regulation of fatty acid biosynthetic process

determination method

regulation of Cdc42 protein signal transduction

determination method

1 reference

8 April 2019

Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

lipid metabolism

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

negative regulation of high-density lipoprotein particle clearance

determination method

1 reference

17 October 2017

Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

phospholipid efflux

determination method

1 reference

8 April 2019

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

negative regulation of low-density lipoprotein particle clearance

determination method

1 reference

17 October 2017

Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

negative regulation of very-low-density lipoprotein particle clearance

determination method

1 reference

17 October 2017

Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

retinoid metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

negative regulation of receptor-mediated endocytosis

determination method

1 reference

8 April 2019

Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

lipid catabolic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

negative regulation of lipoprotein lipase activity

determination method

3 references

17 October 2017

Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

17 October 2017

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

17 October 2017

Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

cholesterol homeostasis

determination method

1 reference

17 October 2017

ABCA1 promotes the de novo biogenesis of apolipoprotein CIII-containing HDL particles in vivo and modulates the severity of apolipoprotein CIII-induced hypertriglyceridemia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

very-low-density lipoprotein particle assembly

determination method

1 reference

8 April 2019

Apolipoprotein C-III: understanding an emerging cardiovascular risk factor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

negative regulation of triglyceride catabolic process

determination method

negative regulation of lipid catabolic process

determination method

1 reference

8 April 2019

Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

negative regulation of lipid metabolic process

determination method

1 reference

8 April 2019

Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

reverse cholesterol transport

determination method

1 reference

8 April 2019

Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

triglyceride homeostasis

determination method

1 reference

17 October 2017

ABCA1 promotes the de novo biogenesis of apolipoprotein CIII-containing HDL particles in vivo and modulates the severity of apolipoprotein CIII-induced hypertriglyceridemia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

triglyceride metabolic process

determination method

1 reference

8 April 2019

Longitudinal analysis of haplotypes and polymorphisms of the APOA5 and APOC3 genes associated with variation in serum triglyceride levels: the Bogalusa Heart Study

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

triglyceride catabolic process

determination method

1 reference

8 April 2019

Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

chylomicron remodeling

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

chylomicron assembly

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

lipoprotein metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02656&geneProductId=UniProtKB:P02656

determination method

negative regulation of triglyceride catabolic process

determination method

3 references

8 April 2019

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

8 April 2019

Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

negative regulation of very-low-density lipoprotein particle clearance

determination method

negative regulation of high-density lipoprotein particle clearance

determination method

negative regulation of low-density lipoprotein particle clearance

determination method

cholesterol homeostasis

determination method

negative regulation of lipoprotein lipase activity

determination method

4 references

8 April 2019

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

8 April 2019

Characterization of the lipid-binding properties and lipoprotein lipase inhibition of a novel apolipoprotein C-III variant Ala23Thr

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

8 April 2019

Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02656

determination method

triglyceride homeostasis

determination method

Gene Atlas image

PBB GE APOC3 205820 s at fs.png
732 × 530; 8 KB

0 references

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000227667

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000227667

ENSP00000364494

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000364494

ENSP00000410614

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000410614

ENSP00000486182

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486182

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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