(Q408249)

Concanavalin A-like lectin/glucanase domain superfamily

1 reference

Tripartite motif-containing protein 5

1 reference

RING-type zinc-finger, LisH dimerisation motif, protein family

1 reference

Butyrophylin-like, SPRY domain, protein family

1 reference

B30.2/SPRY domain, protein family

1 reference

B-box-type zinc finger, protein family

1 reference

Zinc finger, RING-type, protein family

1 reference

SPRY domain, protein family

1 reference

Zinc finger, RING-type, conserved site, protein family

1 reference

protein-macromolecule adaptor activity

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

protein homodimerization activity

1 reference

8 April 2019

The tripartite motif family identifies cell compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

pattern recognition receptor activity

1 reference

8 April 2019

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

zinc ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

1 reference

8 April 2019

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

1 reference

8 April 2019

protein binding

6 references

8 April 2019

TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

8 April 2019

p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

8 April 2019

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

8 April 2019

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

8 April 2019

PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

8 April 2019

Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

identical protein binding

protein kinase binding

1 reference

8 April 2019

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

1 reference

8 April 2019

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

3 references

8 April 2019

8 April 2019

TRIM E3 ligases interfere with early and late stages of the retroviral life cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

8 April 2019

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

1 reference

8 April 2019

TAS

omegasome

1 reference

8 April 2019

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

intracellular anatomical structure

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9C035&geneProductId=UniProtKB:Q9C035

1 reference

16 July 2018

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

1 reference

8 April 2019

P-body

1 reference

8 April 2019

p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

regulation of lipopolysaccharide-mediated signaling pathway

biological process

1 reference

8 April 2019

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

interferon-gamma-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

1 reference

8 April 2019

protein K63-linked ubiquitination

TAS

1 reference

8 April 2019

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

1 reference

8 April 2019

protein trimerization

1 reference

1 January 2018

Unique features of TRIM5alpha among closely related human TRIM family members

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9C035&geneProductId=UniProtKB:Q9C035

positive regulation of DNA-binding transcription factor activity

1 reference

8 April 2019

TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

regulation of protein localization

1 reference

8 April 2019

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

8 April 2019

8 April 2019

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

positive regulation of NF-kappaB transcription factor activity

defense response to virus

TRIM5α and Species Tropism of HIV/SIV

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

TAS

8 April 2019

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

8 April 2019

protein ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

1 reference

8 April 2019

activation of innate immune response

1 reference

8 April 2019

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

positive regulation of I-kappaB kinase/NF-kappaB signaling

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

8 April 2019

8 April 2019

TRIM E3 ligases interfere with early and late stages of the retroviral life cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

1 reference

8 April 2019

positive regulation of MAPK cascade

1 reference

8 April 2019

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

pattern recognition receptor signaling pathway

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

negative regulation of viral entry into host cell

1 reference

8 April 2019

TRIM E3 ligases interfere with early and late stages of the retroviral life cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9C035

http://purl.uniprot.org/uniprot/Q9C035

Gene Atlas image

PBB GE TRIM5 210705 s at fs.png
732 × 530; 12 KB

0 references

exact match

1 reference

Zinc finger, RING-type, conserved site

Identifiers.org

has part(s)

1 reference

Zinc finger, RING-type

1 reference

Butyrophylin-like, SPRY domain

1 reference

SPRY domain

1 reference

B30.2/SPRY domain

1 reference

RING-type zinc-finger, LisH dimerisation motif

1 reference

B-box-type zinc finger

1 reference