(Q421859)

interleukin-8

1 reference

Chemokine interleukin-8-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CXC Chemokine domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CXC chemokine, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

7 references

8 April 2019

Involvement of alpha-2-macroglobulin receptor in clearance of interleukin 8-alpha-2-macroglobulin complexes by human alveolar macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

Mycobacterium tuberculosis AtsG (Rv0296c), GlmU (Rv1018c) and SahH (Rv3248c) Proteins Function as the Human IL-8-Binding Effectors and Contribute to Pathogen Entry into Human Neutrophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

Mycobacterium tuberculosis AtsG (Rv0296c), GlmU (Rv1018c) and SahH (Rv3248c) Proteins Function as the Human IL-8-Binding Effectors and Contribute to Pathogen Entry into Human Neutrophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

4 references

16 July 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

16 July 2018

Autocrine growth effect of IL-8 and GROalpha on a human pancreatic cancer cell line, Capan-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

16 July 2018

Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

5 references

8 April 2019

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

Autocrine growth effect of IL-8 and GROalpha on a human pancreatic cancer cell line, Capan-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

intracellular anatomical structure

cell component

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

3 references

8 April 2019

Inflammation in the developing human intestine: A possible pathophysiologic contribution to necrotizing enterocolitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

intracellular signal transduction

biological process

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

chemokine-mediated signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

cellular response to tumor necrosis factor

1 reference

8 April 2019

Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

IEP

receptor internalization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

cellular response to fibroblast growth factor stimulus

1 reference

8 April 2019

Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

response to endoplasmic reticulum stress

IEP

1 reference

8 April 2019

Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

positive regulation of angiogenesis

1 reference

8 April 2019

CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

regulation of single stranded viral RNA replication via double stranded DNA intermediate

1 reference

8 April 2019

Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

PERK-mediated unfolded protein response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

induction of positive chemotaxis

1 reference

8 April 2019

Immobilized IL-8 triggers progressive activation of neutrophils rolling in vitro on P-selectin and intercellular adhesion molecule-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

3 references

8 April 2019

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

regulation of cell adhesion

1 reference

8 April 2019

Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

cellular response to interleukin-1

1 reference

8 April 2019

Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

1 reference

8 April 2019

Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

positive regulation of neutrophil chemotaxis

1 reference

8 April 2019

Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy

inflammatory response

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

16 July 2018

Inflammation in the developing human intestine: A possible pathophysiologic contribution to necrotizing enterocolitis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

negative regulation of G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

response to molecule of bacterial origin

1 reference

8 April 2019

A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

cellular response to lipopolysaccharide

1 reference

16 July 2018

A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

embryonic digestive tract development

1 reference

8 April 2019

TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

1 reference

8 April 2019

Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

negative regulation of cell population proliferation

1 reference

8 April 2019

CXC chemokines suppress proliferation of myeloid progenitor cells by activation of the CXC chemokine receptor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

calcium-mediated signaling

1 reference

8 April 2019

Ca(2+) signalling by recombinant human CXCR2 chemokine receptors is potentiated by P2Y nucleotide receptors in HEK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

regulation of entry of bacterium into host cell

1 reference

8 April 2019

Mycobacterium tuberculosis AtsG (Rv0296c), GlmU (Rv1018c) and SahH (Rv3248c) Proteins Function as the Human IL-8-Binding Effectors and Contribute to Pathogen Entry into Human Neutrophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

Immobilized IL-8 triggers progressive activation of neutrophils rolling in vitro on P-selectin and intercellular adhesion molecule-1

neutrophil chemotaxis

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

16 July 2018

Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy

neutrophil activation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

antimicrobial humoral immune response mediated by antimicrobial peptide

1 reference

27 February 2018

Potent and broad-spectrum antimicrobial activity of CXCL14 suggests an immediate role in skin infections.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10145&geneProductId=UniProtKB:P10145

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

cytokine-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy

inflammatory response

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

Inflammation in the developing human intestine: A possible pathophysiologic contribution to necrotizing enterocolitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

Immobilized IL-8 triggers progressive activation of neutrophils rolling in vitro on P-selectin and intercellular adhesion molecule-1

neutrophil chemotaxis

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

antimicrobial humoral immune response mediated by antimicrobial peptide

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10145

imported from Wikimedia project

Gene Atlas image

PBB GE IL8 211506 s at.png
255 × 135; 556 bytes

1 reference

English Wikipedia

exact match

http://purl.uniprot.org/uniprot/P10145

1 reference

Chemokine interleukin-8-like domain

Identifiers.org

has part(s)

1 reference

CXC chemokine, conserved site

1 reference

CXC Chemokine domain

1 reference

https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:138181

Identifiers

1 reference

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016