(Q45314035)

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Cyclin A:Cdk2-associated events at S phase entry

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-69656)

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8 July 2022

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-69656

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8 July 2022

SCF(Skp2)-mediated degradation of p27/p21

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Inactivation of Cyclin A:Cdk2 complexes by p27/p21

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8 July 2022

The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex

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8 July 2022

Translocation of p27 to the nucleoplasm

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8 July 2022

Translocation of p21 to the nucleus

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8 July 2022

Formation of Cyclin A:Cdk2 complexes

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8 July 2022

Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2

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8 July 2022

Phosphorylation of Cyclin A:Cdk2 at Tyr 15

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8 July 2022

Translocation of Cyclin A:Cdk2 complexes to the nucleus

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8 July 2022

CAK-mediated phosphorylation of Cyclin A:Cdk2

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8 July 2022

Cyclin A:Cdk2 mediated phosphorylation of p27/p21

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8 July 2022

Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2

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8 July 2022

AKT phosphorylates p21Cip1 and p27Kip1

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8 July 2022

Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15

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8 July 2022

Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase

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8 July 2022

Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm

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8 July 2022

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

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8 July 2022

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

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8 July 2022

Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45314035)

Cyclin A:Cdk2-associated events at S phase entry

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