(Q45314062)

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Regulation of PLK1 Activity at G2/M Transition

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2565942)

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8 July 2022

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8 July 2022

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https://identifiers.org/reactome:R-HSA-2565942

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AJUBA binds centrosome-associated AURKA

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AJUBA facilitates AURKA autophosphorylation

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CDK1 phosphorylates BORA

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AURKA phosphorylates PLK1

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BORA binds PLK1 and AURKA

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PLK1 phosphorylates BORA

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Phosphorylated BORA binds SCF-beta-TrCp1/2

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SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA

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PLK1 phosphorylates OPTN

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Phosphorylated OPTN translocates to the nucleus

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Cytosolic PLK1 translocates to the nucleus

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Myosin phosphatase dephosphorylates PLK1

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Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1

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8 July 2022

Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase

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Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

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8 July 2022

Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

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Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression

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8 July 2022

Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry

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8 July 2022

Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45314062)

Regulation of PLK1 Activity at G2/M Transition

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