(Q45314161)

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Macroautophagy

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1632852)

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https://identifiers.org/reactome:R-HSA-1632852

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Active MTORC1 binds the ULK1 complex

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Active MTORC1 phosphorylates ULK1

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p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex

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Rheb in the MTORC1 complex hydrolyses GTP

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MTORC1 dissociates from ULK complex

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ULK1 is dephosphorylated

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p-AMPK:AMP binds the ULK complex

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AMPK (complex) phosphorylates ULK1 (complex)

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Thr-180 of ULK1 is phosphorylated

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ULK1 phosphorylates ATG13 and RB1CC1

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AMBRA1 binds DYNLL1,DYNLL2

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AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex

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ULK1 phosphorylates AMBRA1:BECN1 complex

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BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2

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ULK complex translocates to the ER

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Beclin-1 complex translocates to the ER

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ULK1 phosphorylates Beclin-1

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Beclin-1 complex phosphorylates PtdIns

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The phagophore extends from the PIP3-enriched structure

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MTMR14, MTMR3 dephosphorylate PI3P

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ATG12 binds ATG7 dimer

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ATG12:ATG7:CysO572-ATG7 binds ATG10

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ATG10 transfers ATG12 from ATG7 to ATG10

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ATG10:ATG12:ATG7 dimer dissociates

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ATG10:ATG12 binds ATG5

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ATG10 transfers ATG12 from ATG10 to ATG5

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ATG10 dissociates from ATG12:ATG5

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ATG5:ATG12 binds ATG16L1

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WIPI2 binds ATG12:ATG5:ATG16L

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LC3 is cleaved by ATG4

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LC3:ATG7 dimer binds ATG3

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ATG3 transfers LC3 from ATG7 to ATG3

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ATG7:ATG3:LC3 dissociates

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ATG16L1 complex transfers LC3 from ATG3 to PE

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LC3 de-lipidation by ATG4

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Autophagosome maturation

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ATG12 forms a thioester bond with ATG7 dimer

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A current perspective of autophagosome biogenesis

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8 July 2022

Identifiers

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8 July 2022

(Q45314161)

Macroautophagy

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