(Q45314311)

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EPHB-mediated forward signaling

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-3928662)

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https://identifiers.org/reactome:R-HSA-3928662

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N-WASP binds ARP2/3 and G-actin

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CDC42 and PIP2 bind WASL, activating it

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ITSN1 exchanges GTP for GDP on CDC42, activating it

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KALRN exchanges GTP for GDP on RAC1, activating it

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Recruitment of p190RhoGEF to p-FAK

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PTK2 autophosphorylates at Y397

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PAK1 autophosphorylates

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p190RhoGEF exchanges GTP for GDP on RHOA, activating it

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RHOA:GTP binds ROCK, activating it

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ROCK phosphorylates LIMK1,2

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FYN phosphorylates NMDAR2B

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LIMK phosphorylates CFL1, inactivating it

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EPHB:NMDAR binds TIAM1

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EPHB phosphorylates TIAM1

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EPHB binds p120-RasGAP

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p-TIAM1 exchanges GTP for GDP on RAC1, activating it

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Ras:GTP binds p120-RasGAP

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p120-RasGAP activates GTP hydrolysis on RAS, inactivating it

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p-EPHB phosphorylates SDC2

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'Eph'ective signaling: forward, reverse and crosstalk

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Identifiers

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(Q45314311)

EPHB-mediated forward signaling

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