(Q45314373)

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Signaling by FGFR3 in disease

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5655332)

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8 July 2022

Signaling by FGFR in disease

1 reference

8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-5655332

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8 July 2022

Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2

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8 July 2022

Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA

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8 July 2022

FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors

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8 July 2022

FGFR3 mutant receptor activation

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8 July 2022

Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1

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8 July 2022

Activated FGFR3 point, translocation and fusion mutants bind FRS2

1 reference

8 July 2022

Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1

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8 July 2022

p-4Y-PLCG1 dissociates from activated FGFR3 point and translocation mutants

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8 July 2022

Activated FGFR3 point and translocation mutants bind PLCG1

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8 July 2022

Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange

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8 July 2022

Activated FGFR3 point and translocation mutants phosphorylate PLCG1

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8 July 2022

Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3

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8 July 2022

Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I

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8 July 2022

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

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8 July 2022

Another mutation that results in the substitution of an unpaired cysteine residue in the extracellular domain of FGFR3 in thanatophoric dysplasia type I

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8 July 2022

High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies

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8 July 2022

A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene

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8 July 2022

Achondroplasia is defined by recurrent G380R mutations of FGFR3

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8 July 2022

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8 July 2022

Recurrent FGFR3-TACC3 fusion gene in nasopharyngeal carcinoma

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8 July 2022

Fibroblast growth factors and their receptors in cancer

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8 July 2022

Missense FGFR3 mutations create cysteine residues in thanatophoric dwarfism type I (TD1)

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8 July 2022

FGFR activation in skeletal disorders: too much of a good thing

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8 July 2022

Fibroblast growth factor receptors: lessons from the genes

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8 July 2022

Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia

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8 July 2022

The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma

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8 July 2022

Oncogenic FGFR3 gene fusions in bladder cancer

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8 July 2022

TACC3 protein regulates microtubule nucleation by affecting γ-tubulin ring complexes

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8 July 2022

Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities

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8 July 2022

Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype

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8 July 2022

Identification of targetable FGFR gene fusions in diverse cancers.

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8 July 2022

Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours

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8 July 2022

Mutant fibroblast growth factor receptor 3 induces intracellular signaling and cellular transformation in a cell type- and mutation-specific manner

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8 July 2022

Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia

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8 July 2022

Craniosynostosis associated with FGFR3 pro250arg mutation results in a range of clinical presentations including unisutural sporadic craniosynostosis

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8 July 2022

Stop codon FGFR3 mutations in thanatophoric dwarfism type 1.

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8 July 2022

Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas.

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8 July 2022

Identical mutations in three different fibroblast growth factor receptor genes in autosomal dominant craniosynostosis syndromes

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8 July 2022

A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia

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8 July 2022

Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3.

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8 July 2022

FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer

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8 July 2022

Frequency of fibroblast growth factor receptor 3 mutations in sporadic tumours.

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8 July 2022

Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia

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8 July 2022

Identifiers

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8 July 2022

(Q45314373)

Signaling by FGFR3 in disease

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