(Q45316747)

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Degradation of the extracellular matrix

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1474228)

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extracellular matrix disassembly

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Extracellular matrix organization

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https://identifiers.org/reactome:R-HSA-1474228

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Activation of Matrix Metalloproteinases

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Elastin degradation by elastin-degrading extracellular proteinases

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Elastin degradation by MMP14

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Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13

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Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS

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Fibrillin-1 degradation by MMP3, CTSK, CTSL2

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Fibrillin-1 degradation by ELANE

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Fibrillin-1 degradation by MMP14

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Fibronectin degradation by MMP10

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Laminin-332 degradation by laminin-322 degrading extracellular proteinases

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Fibronectin degradation by MMP14, TMPRSS6

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Fibronectin degradation by CTSG

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Fibronectin degradation by ADAM8

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Laminin-322 degradation by MMP14

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NID1 degradation by MMP1, 9, 12, ELANE

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Laminin-511 degradation by MMP14

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NID1 degradation by MMP3, 7

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NID1 degradation by MMP14, MMP15

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NID1 degradation by MMP19

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Aggrecan degradation by ADAMTSs

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Brevican degradation by ADAMTS4, ADAMTS5

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Aggrecan degradation by MMP1,2,3,7,9,12,13

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HTRA1 hydrolyzes ACAN (Aggrecan)

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Brevican degradation by MMP1, 2, 3, 7,8,10,13,19

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HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)

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HSPG2 (perlecan) degradation by MMP13, CTSS

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HSPG2 (perlecan) degradation by MMP14, MMP15

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HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1

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DCN (decorin) degradation by MMP2, MMP3, MMP7

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E-cadherin degradation by MMP3, MMP7 and plasmin.

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E-cadherin degradation by PS1:NCSTN (Gamma-secretase)

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E-cadherin degradation by MMP9, KLK7

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DCN (decorin) degradation by MMP14

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E-cadherin degradation by ADAM10, ADAM15

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MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin

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MMP2, MMP7, MMP9 bind CD44

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E-cadherin degradation by caspase-3 and calpain-1

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Basigin binds Matrix metalloproteinase-1

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OPN (osteopontin) degradation by MMP3, MMP7

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CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins

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MMP2, MMP9 cleave SCUBE3

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SCUBE1, SCUBE3 oligomerize

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Extracellular matrix degradation and remodeling in development and disease

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Identifiers

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8 July 2022

(Q45316747)

Degradation of the extracellular matrix

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