(Q45316805)

English

RUNX1 regulates transcription of genes involved in differentiation of HSCs

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-8939236)

In more languages

default values for all languages

No label defined

No description defined

edit

Statements

1 reference

8 July 2022

regulation of hematopoietic stem cell differentiation

1 reference

8 July 2022

Transcriptional regulation by RUNX1

1 reference

13 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-8939236

1 reference

8 July 2022

KMT2A (MLL) binds RUNX1

1 reference

8 July 2022

RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene

1 reference

8 July 2022

KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark

1 reference

8 July 2022

SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A

1 reference

8 July 2022

RUNX1 binds the core TAL1 complex

1 reference

8 July 2022

RUNX1-containing TAL1 complex binds the MYB gene enhancer

1 reference

8 July 2022

MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex

1 reference

8 July 2022

1 reference

8 July 2022

The complex of RUNX1 and YAP1 binds the ITCH gene promoter

1 reference

8 July 2022

ITCH gene expression is stimulated by RUNX1 and YAP1

1 reference

8 July 2022

ABL1 phosphorylates YAP1

1 reference

8 July 2022

1 reference

8 July 2022

TP73 tetramer translocates to the nucleus

1 reference

8 July 2022

ITCH polyubiquitinates TP73

1 reference

8 July 2022

26S proteasome degrades TP73 polyubiquitinated by ITCH

1 reference

8 July 2022

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

1 reference

8 July 2022

The RUNX1-PU.1 axis in the control of hematopoiesis.

1 reference

8 July 2022

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.

1 reference

8 July 2022

Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.

1 reference

8 July 2022

Activation of CCAAT/enhancer-binding protein alpha or PU.1 in hematopoietic stem cells leads to their reduced self-renewal and proliferation

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q45316805)

RUNX1 regulates transcription of genes involved in differentiation of HSCs

Statements

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)