(Q45316820)

English

Regulation of RUNX2 expression and activity

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-8939902)

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8 July 2022

Transcriptional regulation by RUNX2

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8 July 2022

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https://identifiers.org/reactome:R-HSA-8939902

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Activated ESR1 binds the RUNX2 gene promoter

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ESRRA:PPARG1CA binds the RUNX2 gene promoter

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ESRRA:PPARG1CB binds the RUNX2 gene promoter

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TWIST1 binds the RUNX2 gene promoter

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RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1

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NKX3-2 binds RUNX2 gene promoter

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DEXA:NR3C1 complex binds RUNX2 gene proximal promoter

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RUNX2-P2 binds RUNX2 gene promoter

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RUNX2-P1 binds RUNX2 gene promoter

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RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6)

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DLX5,(DLX6) binds RUNX2 gene promoter

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MSX2 binds RUNX2 gene promoter

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RUNX2 translocates to the nucleus

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RUNX2 binds to HIVEP3 and WWP1

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WWP1 polyubiquitinates RUNX2

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Proteasome degrades polyubiquitinated RUNX2

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GSK3B phosphorylates RUNX2

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FBXW7 binds RUNX2 and GSK3B

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FBXW7 polyubiquitinates RUNX2

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STUB1 polyubiquitinates RUNX2

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RUNX2 binds SMURF1 gene

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Proteasome degrades PolyUb-RUNX2

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SMURF1 polyubiquitinates RUNX2

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SMURF1 gene expression is stimulated by RUNX2

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SCF(SKP2) complex binds RUNX2

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SCF(SKP2) polyubiquitinates RUNX2

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8 July 2022

26S proteasome degrades PolyUb-RUNX2

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8 July 2022

Proteasome degrades polyubiquitinated RUNX2

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8 July 2022

The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development

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8 July 2022

Hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of RUNX2 by TWIST

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8 July 2022

E3 Ubiquitin Ligase Smurf1 Mediates Core-binding Factor α1/Runx2 Degradation and Plays A Specific Role in Osteoblast Differentiation

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8 July 2022

The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen

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8 July 2022

A twist code determines the onset of osteoblast differentiation

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8 July 2022

Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation

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8 July 2022

CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

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8 July 2022

Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation

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8 July 2022

SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation

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8 July 2022

Cbfbeta interacts with Runx2 and has a critical role in bone development

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8 July 2022

Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis

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8 July 2022

E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation.

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8 July 2022

Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter

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Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2.

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8 July 2022

Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3.

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8 July 2022

Mutations in the RUNX2 gene in patients with cleidocranial dysplasia

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A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development

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8 July 2022

Advances in Runx2 regulation and its isoforms

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8 July 2022

Estrogen Receptor α (ERα) and Estrogen Related Receptor α (ERRα) are both transcriptional regulators of the Runx2-I isoform

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8 July 2022

Core-binding factor beta interacts with Runx2 and is required for skeletal development

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8 July 2022

A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells

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8 July 2022

Identifiers

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8 July 2022

(Q45316820)

Regulation of RUNX2 expression and activity

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