(Q45316881)

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TET1,2,3 and TDG demethylate DNA

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5221030)

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8 July 2022

oxidative DNA demethylation

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Epigenetic regulation of gene expression

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-5221030

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TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine

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TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine

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TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine

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TDG excises 5-formylcytosine

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TDG excises 5-carboxylcytosine

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Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

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Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

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8 July 2022

A mechanistic overview of TET-mediated 5-methylcytosine oxidation

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

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Role of TET enzymes in DNA methylation, development, and cancer

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Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells.

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Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

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8 July 2022

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation

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Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells

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Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine

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8 July 2022

TET enzymes, TDG and the dynamics of DNA demethylation.

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8 July 2022

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

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8 July 2022

Ten eleven translocation enzymes and 5-hydroxymethylation in mammalian development and cancer

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TET enzymatic oxidation of 5-methylcytosine, 5-hydroxymethylcytosine and 5-formylcytosine.

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TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation

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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

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8 July 2022

Tet1 regulates adult hippocampal neurogenesis and cognition

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8 July 2022

5-Methylcytosine DNA demethylation: more than losing a methyl group

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45316881)

TET1,2,3 and TDG demethylate DNA

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