(Q45316910)

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Thrombin signalling through proteinase activated receptors (PARs)

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-456926)

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1 reference

8 July 2022

Platelet activation, signaling and aggregation

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-456926

1 reference

8 July 2022

Activated thrombin (factor IIa) cleaves PAR3,4, activating them

1 reference

8 July 2022

Thrombin-activated PARs binds G-protein Gq

1 reference

8 July 2022

Thrombin-activated PARs activate Gq

1 reference

8 July 2022

Thrombin-activated PARs:Gq (active) dissociate

1 reference

8 July 2022

Thrombin-activated PARs binds G-protein G12/13

1 reference

8 July 2022

Thrombin-activated PARs activate G12/13

1 reference

8 July 2022

Thrombin-activated PARs:G12/13 (active) dissociate

1 reference

8 July 2022

1 reference

8 July 2022

1 reference

8 July 2022

F2R:ARRB1 binds MAPKs, SRC-1

1 reference

8 July 2022

F2R:ARRB2 binds MAPKs, SRC-1

1 reference

8 July 2022

SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)

1 reference

8 July 2022

SRC-1 bound to ARRB2 is not activated

1 reference

8 July 2022

Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)

1 reference

8 July 2022

Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it

1 reference

8 July 2022

pro-F2R binds vorapaxar

1 reference

8 July 2022

Thrombin signalling and protease-activated receptors

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q45316910)

Thrombin signalling through proteinase activated receptors (PARs)

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