(Q45316926)

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Intrinsic Pathway of Fibrin Clot Formation

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-140837)

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8 July 2022

blood coagulation, intrinsic pathway

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Formation of Fibrin Clot (Clotting Cascade)

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https://identifiers.org/reactome:R-HSA-140837

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kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer

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prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer

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prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer

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kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin

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factor XII -> factor XIIa

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factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex

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factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer

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factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)

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factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)

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factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)

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factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer

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factor VIIIa associates with cell membrane

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factor IXa associates with cell membrane

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factor VIIIa + factor IXa -> factor VIIIa:factor IXa

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factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)

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kallikrein binds SERPING1

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kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin

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factor XIIa binds SERPING1

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Factor IIa inhibitors (compounds) binds IIa

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Factor IIa inhibitors (peptide) binds IIa

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Factor VIIIa dissociates

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The coagulation cascade: initiation, maintenance, and regulation

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Platelets and thrombin generation

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The physiologic basis of assembly and activation of the plasma kallikrein/kinin system

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8 July 2022

Tissue factor pathway inhibitor and the revised theory of coagulation

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8 July 2022

Identifiers

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8 July 2022

(Q45316926)

Intrinsic Pathway of Fibrin Clot Formation

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