(Q45316934)

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Factors involved in megakaryocyte development and platelet production

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-983231)

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8 July 2022

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https://identifiers.org/reactome:R-HSA-983231

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RAD51B:RAD51C binds single-stranded DNA

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Dual-specific AKAPs bind type I and II PKA regulatory subunits

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Mitofusins trans-interact linking mitochondria prior to fusion

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p53, SIN3A and MYB form a complex

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8 July 2022

IRF1 binds the promoters of Interferon alpha and beta

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Expression of Interferon-alpha and beta

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IRF2 binds the promoters of Interferon alpha and beta

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HP1 alpha binds Histone H3K9(me)3

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ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5

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ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4

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ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4

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LRRC16A binds F-actin capping protein

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F-actin capping protein is a heterodimer

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F-actin capping protein binds to the barbed end of elongating F-actin

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MICAL1 produces NADP+, H2O2

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REST recruits the BHC complex

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ZFPM proteins bind GATA proteins

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JMJD1C demethylates H3K9 mono- and di-methylation

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SH2B proteins bind JAK2

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Adenylate Kinase 3 is a GTP-AMP phosphotransferase

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NFE2 binds the beta globin locus control region

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Expression of globin genes under control of the beta globin control region

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NFE2 is a heterodimer

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EHD proteins interact with Rabenosyn-5

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Rabenosyn-5 connects Rab5 to VPS-45

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DOCKs bind to RhoGEFs

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Cables link CDK5 and ABL1

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Cables1 links CDK2 and WEE1

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From hematopoietic stem cells to platelets.

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Megakaryocyte development and platelet production.

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Transcriptional control of megakaryocyte development

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8 July 2022

Identifiers

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8 July 2022

(Q45316934)

Factors involved in megakaryocyte development and platelet production

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