(Q45316971)

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MHC class II antigen presentation

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2132295)

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1 reference

8 July 2022

antigen processing and presentation of exogenous peptide antigen via MHC class II

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8 July 2022

Adaptive Immune System

1 reference

13 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-2132295

1 reference

8 July 2022

Formation of MHC II alpha beta heterodimer

1 reference

8 July 2022

Interaction of invariant chain trimer and MHC II alpha beta dimer

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8 July 2022

Formation of nonameric complex

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8 July 2022

Dissociation of CANX from nonameric complex

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8 July 2022

Formation of COPII vesicle

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8 July 2022

Fusion of COPII vesicle with Golgi complex

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8 July 2022

Transport of MHC II:Ii complex along Golgi to TGN

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8 July 2022

TGN-lysosomal vesicle coat assembly

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8 July 2022

Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex

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8 July 2022

Translocation of TGN-lysosome vesicle to lysosome

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8 July 2022

TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome

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8 July 2022

Transport of MHC II:Ii complex to plasma membrane

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8 July 2022

Insertion of MHC II:Ii complex in to the plasma membrane

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8 July 2022

Recruitment of clathrin coated vesicle by Ii

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8 July 2022

Internalization of MHC II:Ii clathrin coated vesicle

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8 July 2022

Uncoating of clathrin-coated vesicles and fusion with endosomes

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8 July 2022

Trafficking of nonameric complex in the endocytic pathway

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8 July 2022

Initial proteolyis of Ii by aspartic proteases to lip22

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8 July 2022

Cleavage of lip22 to lip10

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8 July 2022

Generation of CLIP from lip10

1 reference

8 July 2022

Disassociation of CLIP from MHC II

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8 July 2022

MHC class II antigen internalization

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8 July 2022

Reduction of disulphide bonds in MHC II antigens

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8 July 2022

MHC class II antigen processing

1 reference

8 July 2022

Loading of antigenic peptides

1 reference

8 July 2022

Transport of antigen loaded MHC II molecules to surface

1 reference

8 July 2022

LAG3 (CD233) binds MHC II

1 reference

8 July 2022

Presentation of antigens by MHC class II molecules: getting the most out of them

1 reference

8 July 2022

MHC molecules and microbial antigen processing in phagosomes

1 reference

8 July 2022

How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway

1 reference

8 July 2022

MHC II and the endocytic pathway: regulation by invariant chain.

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q45316971)

MHC class II antigen presentation

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