(Q45317023)

English

Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-936964)

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1 reference

8 July 2022

TRIF-dependent toll-like receptor signaling pathway

1 reference

8 July 2022

TRIF(TICAM1)-mediated TLR4 signaling

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-936964

1 reference

8 July 2022

Dimerization of phosphorylated IRF3/IRF7

1 reference

8 July 2022

Dimerized phospho-IRF3/IRF7 is transported to the nucleus

1 reference

8 July 2022

TRAF3 binds TICAM1:activated TLR4 complex

1 reference

8 July 2022

Auto-ubiquitination of TRAF3

1 reference

8 July 2022

TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4

1 reference

8 July 2022

TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4

1 reference

8 July 2022

Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation

1 reference

8 July 2022

IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4

1 reference

8 July 2022

Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex

1 reference

8 July 2022

Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity

1 reference

8 July 2022

The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection

1 reference

8 July 2022

Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling

1 reference

8 July 2022

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q45317023)

Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

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