(Q45317045)

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Regulation of Complement cascade

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-977606)

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8 July 2022

regulation of complement activation

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8 July 2022

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https://identifiers.org/reactome:R-HSA-977606

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C3 convertases spontaneously dissociate

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Factor H binds to C3b

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Factor H binds host cell surface markers

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Factor H binds to membrane-associated C3b

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Factor H binds to C3bBb

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Factor H displaces Bb

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Complement factor I complex formation

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Complement factor I binds to extracellular Factor H:C3b

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Factor I inactivates plasma Factor H-bound C3b

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Complement factor I binds to membrane-associated Factor H:C3b

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Factor I inactivates Factor H-boundC3b

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Factor I cleaves iC3b

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CR1 binds C3bBb/C4bC2a

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Displacement of C2a/Bb by CR1

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CR2 binds C3d, C3dg, iC3b

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CR2:C3d,C3dg,iC3b binds CD19:CD81

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Complement factor I binds to MCP, CR1:C4b, C3b

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Factor I inactivates MCP/CR1-bound C4b/C3b

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CD55 (DAF) binds C3bBb, C4bC2a

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CD55 (DAF) promotes C3bBb/C4bC2a dissociation

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C4b-binding protein binds C4b

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Complement factor I binds C4BP

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Complement factor I inactivates C4BP-bound C4b

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C4b binding protein binds C4bC2a

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C4b binding protein displaces C2a

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C4b binding protein binds Protein S

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CD59 inhibits MAC formation

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Formation of soluble VTN:C5b-C9

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Vitronectin (VTN) binds to C5b:C6:C7

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Hydrolysis of internal thioester in C4b

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C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s

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Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates

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C3a receptor binds anaphylatoxin C3a

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C5a receptor binds C5a anaphylatoxin

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Clusterin binds C5b-C7, C8, C9

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C5AR2 binds anaphylatoxins and thier desArginated derivatives

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Thrombin, ELANE cleave C5

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CPN, CPB2 cleave C3a, C5a

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C1-Inh binds and inactivates C1r, C1s

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8 July 2022

Complement: a key system for immune surveillance and homeostasis

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8 July 2022

Complement: a unique innate immune sensor for danger signals

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8 July 2022

Complement regulators and inhibitory proteins

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8 July 2022

Identifiers

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8 July 2022

(Q45317045)

Regulation of Complement cascade

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