(Q45317088)

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CLEC7A (Dectin-1) signaling

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5607764)

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C-type lectin receptors (CLRs)

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https://identifiers.org/reactome:R-HSA-5607764

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Dectin-1 mediated noncanonical NF-kB signaling

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CLEC7A (Dectin-1) induces NFAT activation

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CLEC7A/inflammasome pathway

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Ubiquitination of NEMO by TRAF6

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p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB

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beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex

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26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex

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NFKB1:RELA translocates from the cytosol to the nucleus

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CLEC7A binds 1,3-beta-D-glucan

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SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan

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SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan

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1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG

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p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane

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p-Y753,Y759-PLCG2 hydrolyses PIP2

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PKC-delta translocates to plasma membrane

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PKC-delta is activated

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PKC-delta phosphorylates CARD9

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TRAF6 binds MALT1 oligomers

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TRAF6 oligomer autoubiquitinates

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TRIKA2 binds K63polyUb-TRAF6 oligomer

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K63polyUb-TRAF6 ubiquitinates TAK1

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K63polyUb-TAK1 autophosphorylates

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K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta

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Pattern recognition: recent insights from Dectin-1

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Dectin-1 mediates the biological effects of beta-glucans

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Identifiers

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8 July 2022

(Q45317088)

CLEC7A (Dectin-1) signaling

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