(Q45317129)

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Interleukin-4 and Interleukin-13 signaling

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-6785807)

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cytokine-mediated signaling pathway

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Signaling by Interleukins

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13 July 2022

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https://identifiers.org/reactome:R-HSA-6785807

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Expression of IL18, ALOX5

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IL4:IL4R:JAK2 binds IL2RG:JAK3

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IL4:IL4R:JAK2 binds IL13RA1:TYK2

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JAK1 binds IL4R in IL4-bound IL4R1

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IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated

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STAT3,STAT6 bind p-Y-IL4R

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JAK1 phosphorylates STAT3,STAT6

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p-Y705-STAT3,p-Y641-STAT6 dissociate

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p-Y705-STAT3, p-Y641-STAT6 dimerise

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p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus

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Expression of STAT6-upregulated extracellular proteins

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Expression of STAT6-upregulated plasma membrane proteins

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Expression of STAT3-upregulated extracellular proteins

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Expression of STAT3-upregulated plasma membrane proteins

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Expression of STAT3-upregulated cytosolic proteins

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Expression of STAT3-upregulated nuclear proteins

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Expression of BCL2, BCL2L1

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Expression of HSP90B1

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Expression of NDN,TP53

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SOCS5,(SOCS1) bind IL4RA

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IL13 binds IL13RA:TYK2

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IL13:IL13RA:TYK2 binds IL4R:JAK2

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JAK1 binds IL4R in IL13-bound IL13R type II

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IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated

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STAT1,STAT3,STAT6 bind IL13:IL13R type II

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STAT1,STAT3,STAT6 phosphorylation

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p-Y-STATs translocate to nucleus

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Expression of IL4, IL13-upregulated extracellular proteins

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Expression of HSPA8, ALOX15

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Expression of IL4,IL13-downregulated extracellular genes

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Expression of IL13-upregulated plasma membrane proteins

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Expression of IL13-downregulated extracellular proteins

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JAK3 binds JAK3 inhibitors

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The IL-4 receptor: signaling mechanisms and biologic functions

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IL-13 receptors and signaling pathways: An evolving web

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Identifiers

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(Q45317129)

Interleukin-4 and Interleukin-13 signaling

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