(Q45317232)

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Synthesis of Leukotrienes (LT) and Eoxins (EX)

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2142691)

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8 July 2022

leukotriene metabolic process

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8 July 2022

Arachidonic acid metabolism

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https://identifiers.org/reactome:R-HSA-2142691

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ALOX5 is phosphorylated by MAPKAP2

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Arachidonic acid is oxidised to 5S-HpETE by ALOX5

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5S-HpETE is dehydrated to LTA4 by ALOX5

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LTA4 is hydolysed to LTB4 by LTA4H

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LTB4 is oxidised to 12-oxoLTB4 by PTGR1

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CYP4F2, 4F3 20-hydroxylate LTB4

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20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3

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20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3

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20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH

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20cooh-LTB4 is converted to 18cooh-LTB4

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LTA4 is converted to LTC4 by LTC4S

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LTC4 is exported from the cytosol by ABCC1

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GGT1, 5 dimers hydrolyse LTC4 to LTD4

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LTD4 is converted to LTE4 by DPEP1/2

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LTA4 is hydrolysed to 6t-/6t,12epi-LTB4

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LTA4 is converted to EXA4 by ALOX15

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EXA4 is converted to EXC4 by LTC4S

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EXC4 is converted to EXD4 by GGT

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EXD4 is converted to EXE4 by DPEP

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ALOX5 binds ALOX5 inhibitors

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8 July 2022

On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma

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8 July 2022

Biosynthesis and metabolism of leukotrienes

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8 July 2022

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8 July 2022

Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45317232)

Synthesis of Leukotrienes (LT) and Eoxins (EX)

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