(Q45317319)

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Regulation of cholesterol biosynthesis by SREBP (SREBF)

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1655829)

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8 July 2022

regulation of cholesterol biosynthetic process

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8 July 2022

Metabolism of steroids

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8 July 2022

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https://identifiers.org/reactome:R-HSA-1655829

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Activation of gene expression by SREBF (SREBP)

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SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum

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SREBP1A,1C,2 binds SCAP:INSIG:oxysterol and is retained in the endoplasmic reticulum

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SREBP1A,1C,2:SCAP binds CopII Coat Complex

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SREBP1A,1C,2:SCAP translocates to the Golgi

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S1P hydrolyzes SREBP1A,1C,2

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S2P hydrolyzes SREBP1A,1C,2

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SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers

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SREBP1A,1C,2 binds Importin beta-1

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SREBP1A,1C,2 translocates to the nucleus

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SREBP1A,1C,2:Importin beta-1 dissociates

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Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been

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Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins

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8 July 2022

Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL

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8 July 2022

Identifiers

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8 July 2022

(Q45317319)

Regulation of cholesterol biosynthesis by SREBP (SREBF)

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