(Q45317323)

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Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-193368)

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bile acid biosynthetic process

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Synthesis of bile acids and bile salts

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https://identifiers.org/reactome:R-HSA-193368

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CYP7A1 7-hydroxylates CHOL

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7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one

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CYP8B1 12-hydroxylates 4CHOL7aOLONE

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4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one

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4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one

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5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol

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5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol

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5beta-cholestan-3alpha, 7alpha, 12alpha-triol is translocated from the cytosol to the mitochondrial matrix

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5beta-cholestan-3alpha, 7alpha-diol is translocated from the cytosol to the mitochondrial matrix

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CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol

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5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al

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5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol

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5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al

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3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)

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3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)

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THCA is translocated from the mitochondrial matrix to the cytosol

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DHCA is translocated from the mitochondrial matrix to the cytosol

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THCA is conjugated with Coenzyme A (SLC27A2 VLCS)

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DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)

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THCA is conjugated with Coenzyme A (SLC27A5 BACS)

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DHCA is conjugated with Coenzyme A (SLC27A5 BACS)

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25(R) THCA-CoA is translocated from the cytosol to the peroxisome

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25(R) DHCA-CoA is translocated from the cytosol to the peroxisome

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Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA

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Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA

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25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)

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25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA

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3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA

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25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA

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(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA

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(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA

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Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA

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Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA

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Hydrolysis of choloyl-CoA to cholate and CoASH

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Cholate is translocated from the peroxisomal matrix to the cytosol

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Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate

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Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate

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Bile salts are translocated from the peroxisomal matrix to the cytosol

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ABCB11 transports bile salts from cytosol to extracellular region

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The enzymes, regulation, and genetics of bile acid synthesis

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Identifiers

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(Q45317323)

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

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