(Q45317372)

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Citric acid cycle (TCA cycle)

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-71403)

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tricarboxylic acid cycle

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Pyruvate metabolism and Citric Acid (TCA) cycle

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https://identifiers.org/reactome:R-HSA-71403

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GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA

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NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]

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Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA

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(S)-Malate <=> Fumarate + H2O

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Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+

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(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+

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Fumarate + H2O <=> (S)-Malate

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citrate <=> isocitrate

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isocitrate <=> citrate

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isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]

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isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]

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alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+

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Succinate <=> Fumarate (with FAD redox reaction on enzyme)

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ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA

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FAHD1:Zn2+ dimer hydrolyses OA to PYR

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ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR

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ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR

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The pursuit of a hobby

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The formation of citric and alpha-ketoglutaric acids in the mammalian body

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The oxidation of pyruvate in pigeon breast muscle

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Identifiers

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(Q45317372)

Citric acid cycle (TCA cycle)

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