(Q45317482)

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Phase I - Functionalization of compounds

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-211945)

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xenobiotic metabolic process

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Biological oxidations

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https://identifiers.org/reactome:R-HSA-211945

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Cytochrome P450 - arranged by substrate type

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Amine Oxidase reactions

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FMO oxidises nucleophiles

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Aryl hydrocarbon receptor signalling

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ALD3A1 oxidises 4HPCP to CXPA

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CES1 trimer.CES2 hydrolyse COCN to BEG

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EPHX1 hydrates BaP4,5O to BaP4,5-DHD

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AADAC deacetylates PHEN

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BPHL hydrolyses VACV to ACV

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CMBL hydrolyses OM to OLMS

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MARC1,MARC2 reduce N-hydroxylated compounds

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NQO2:FAD dimer reduces quinones to hydroquinones

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CBR3 reduces DOX to DOXOL

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CES3 hydrolyses CHEST to CHOL and LCFA(-)

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CYP3A4, CYP2B6 bind ritonavir

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CYP3A4 binds CYP3A4 inhibitors

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Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics

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Cytochrome P450s and other enzymes in drug metabolism and toxicity

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The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans

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Identifiers

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8 July 2022

(Q45317482)

Phase I - Functionalization of compounds

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